| Gene Symbol | PRKCH |
|---|---|
| Entrez Gene | 5583 |
| Alt Symbol | PKC-L, PKCL, PRKCL, nPKC-eta |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein kinase C, eta |
| Other Description | protein kinase C eta type |
| Swissprots | P24723 Q8NE03 Q16246 B4DJN5 |
| Accessions | AAD12779 CAH05605 CBX47631 EAW80800 EAW80801 EAW80802 P24723 AB451313 BAG70127 AK093241 AK290183 BAF82872 AK296158 BAG58897 AK300864 BAG62513 AW008462 AX775931 CAE11665 AX775933 CAE11666 BC001000 AAH01000 BC037268 AAH37268 BP367689 CA447784 CB994021 CD522081 DQ890890 ABM81816 DQ894045 ABM84971 M55284 AAA60100 S74620 AAB32724 XM_011536954 XP_011535256 XM_011536955 XP_011535257 XM_011536956 XP_011535258 XM_011536957 XP_011535259 NM_006255 NP_006246 |
| Function | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epith |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
| Tissue Specificity | Most abundant in lung, less in heart and skin. {ECO:0000269|PubMed:1986216}. |
| Top Pathways | Tight junction, Vascular smooth muscle contraction, Inflammatory mediator regulation of TRP channels |