PRKCH

Gene Symbol	PRKCH
Entrez Gene	5583
Alt Symbol	PKC-L, PKCL, PRKCL, nPKC-eta
Species	Human
Gene Type	protein-coding
Description	protein kinase C, eta
Other Description	protein kinase C eta type
Swissprots	P24723 Q8NE03 Q16246 B4DJN5
Accessions	AAD12779 CAH05605 CBX47631 EAW80800 EAW80801 EAW80802 P24723 AB451313 BAG70127 AK093241 AK290183 BAF82872 AK296158 BAG58897 AK300864 BAG62513 AW008462 AX775931 CAE11665 AX775933 CAE11666 BC001000 AAH01000 BC037268 AAH37268 BP367689 CA447784 CB994021 CD522081 DQ890890 ABM81816 DQ894045 ABM84971 M55284 AAA60100 S74620 AAB32724 XM_011536954 XP_011535256 XM_011536955 XP_011535257 XM_011536956 XP_011535258 XM_011536957 XP_011535259 NM_006255 NP_006246
Function	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epith
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	Most abundant in lung, less in heart and skin. {ECO:0000269|PubMed:1986216}.
Top Pathways	Tight junction, Vascular smooth muscle contraction, Inflammatory mediator regulation of TRP channels

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PRKCH 293T Cell Transient Overexpression Lysate(Denatured) - H00005583-T02 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

PRKCH overexpression lysate - LY401883 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PRKCH 293 Cell Lysate - 401677 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PKC eta Overexpression Lysate (Denatured) - H00005583-T02 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

PKC eta Overexpression Lysate (Native) - NBL1-14776 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PRKCH Over-expression Lysate Product - GWB-35A41F from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Panoply™ Human PRKCH Knockdown Stable Cell Line - CSC-DC012402 from Creative biogene Category Cell Line Species Human

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