PRKCH

Gene Symbol PRKCH
Entrez Gene 5583
Alt Symbol PKC-L, PKCL, PRKCL, nPKC-eta
Species Human
Gene Type protein-coding
Description protein kinase C, eta
Other Description protein kinase C eta type
Swissprots P24723 Q8NE03 Q16246 B4DJN5
Accessions AAD12779 CAH05605 CBX47631 EAW80800 EAW80801 EAW80802 P24723 AB451313 BAG70127 AK093241 AK290183 BAF82872 AK296158 BAG58897 AK300864 BAG62513 AW008462 AX775931 CAE11665 AX775933 CAE11666 BC001000 AAH01000 BC037268 AAH37268 BP367689 CA447784 CB994021 CD522081 DQ890890 ABM81816 DQ894045 ABM84971 M55284 AAA60100 S74620 AAB32724 XM_011536954 XP_011535256 XM_011536955 XP_011535257 XM_011536956 XP_011535258 XM_011536957 XP_011535259 NM_006255 NP_006246
Function Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epith
Subcellular Location Cytoplasm {ECO:0000250}.
Tissue Specificity Most abundant in lung, less in heart and skin. {ECO:0000269|PubMed:1986216}.
Top Pathways Tight junction, Vascular smooth muscle contraction, Inflammatory mediator regulation of TRP channels

HTScan® PKCη Kinase Assay Kit - 7594 from Cell Signaling Technology

Category Assay Kit
Figure 1. PKCeta kinase activity was measured in a radiometric assay using the following reaction conditions: 60 mM HEPES-NaOH, pH 7.5, 3 mM MgCl2, 3 mM MnCl2, 3 µM Na-orthovanadate, 1.2 mM DTT, 1 µM ATP, 2.5 µg/50 µl PEG20,000, Substrate: Histone H1, variable and Recombinant PKCeta, variable.

PRKCH (Human) IP-WB Antibody Pair - H00005583-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

PKCeta, ELISA Kit - MBS2500376 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.875ng/mL
Range 3.125-200ng/mL

PKCeta, ELISA Kit - MBS2502242 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.094ng/mL
Range 0.156-10ng/mL

PKCeta, ELISA Kit - MBS2500979 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.875ng/mL
Range 3.125-200ng/mL

PKCeta, ELISA Kit - MBS2512775 from MyBioSource

Category ELISA Kit
Prices $410.00, $490.00, $2,040.00, $3,590.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.875mU/mL
Range 3.125--200mU/mL

PKCeta, ELISA Kit - MBS2504388 from MyBioSource

Category ELISA Kit
Prices $490.00, $585.00, $2,475.00, $4,360.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.938ng/mL
Range 1.563-100ng/mL

PKCeta, ELISA Kit - MBS2502633 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.094ng/mL
Range 0.156-10ng/mL

Protein Kinase C Eta (PKCh), ELISA Kit - MBS9308172 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1ng/ml.
Range 0.5 ng/ml - 16 ng/ml.

Protein Kinase C Eta (PKCh), ELISA Kit - MBS9314136 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Eta (PKCh), ELISA Kit - MBS9308134 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

protein kinase C, eta, ELISA Kit - MBS9330239 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human Protein Kinase C Eta Immunofluorescent Assay Kit - DIFT040 from Creative Diagnostics

Category Immunofluorescence Kit

Human PRKCH / PKC-Eta ELISA Kit (Sandwich ELISA) - LS-F20662 from LifeSpan Bioscience

Category ELISA Kit
Prices $590.00
Sizes 1 plate
Sensitivity 3.125
Range 3.125-200 mU/ml

PKCeta (Protein Kinase C Eta), CLIA Kit - MBS2532766 from MyBioSource

Category CLIA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.375mU/mL
Range 0.625-40mU/mL

Human PRKCH ELISA Kit - E031620 from Biobool

Category ELISA Kit

Protein Kinase C Eta (PKCH), ELISA Kit - MBS9365624 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Eta (PKCH), ELISA Kit - MBS9364682 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Eta (PKCH), ELISA Kit - MBS9362876 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Eta (PKCH), ELISA Kit - MBS9356565 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Eta (PKCH), ELISA Kit - MBS9361253 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Eta (PKCH), ELISA Kit - MBS9355571 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Eta (PKCH), ELISA Kit - MBS9361892 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Eta (PKCH), ELISA Kit - MBS9347502 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Eta (PKCH), ELISA Kit - MBS9351144 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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