LAMTOR3

Gene Symbol	LAMTOR3
Entrez Gene	8649
Alt Symbol	MAP2K1IP1, MAPBP, MAPKSP1, MP1, PRO0633, Ragulator3
Species	Human
Gene Type	protein-coding
Description	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Other Description	MAPK scaffold protein 1|MEK binding partner 1|late endosomal/lysosomal adaptor and MAPK and MTOR activator 3|mitogen-activated protein kinase kinase 1 interacting protein 1|mitogen-activated protein kinase scaffold protein 1|ragulator complex protein LAMTOR3
Swissprots	Q9H364 Q9UHA4 J3KMX4 B2R4A1
Accessions	CAT04668 EAX06112 EAX06113 Q9UHA4 AF130115 AAG35540 AF201947 AAF17239 AF305816 AAK55519 AK022313 AK223311 BAD97031 AK311755 BAG34698 AL544981 BC005340 BC026245 AAH26245 BC110402 BI562630 DA300823 DQ893108 ABM84034 DQ896381 ABM87380 NM_001243736 NP_001230665 NM_021970 NP_068805 NR_024170
Function	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22980980}.
Subcellular Location	Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

LAMTOR3/MAPKSP1 (D38G5) Rabbit mAb - 8168 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D38G5

MP1 (H-6) - sc-376783 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

MP1 (B-12) - sc-25345 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

MP1 (FL-124) - sc-9136 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

MP1 (A-19) - sc-8626 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MP1 (A-12) - sc-55481 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Anti-MAP2K1IP1 antibody - ab191581 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAP2K1IP1 antibody - ab96653 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-MAP2K1IP1 antibody - ab76984 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-MAP2K1IP1 antibody [Y130] - ab32134 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone Y130

Anti-LAMTOR3 / MP1 Antibody (aa1-124) - LS-C37384 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-LAMTOR3 / MP1 Antibody (aa20-180, Biotin) - LS-C143568 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LAMTOR3 / MP1 Antibody (aa20-180, DY488) - LS-C143570 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LAMTOR3 / MP1 Antibody (aa20-180, HRP) - LS-C143571 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LAMTOR3 / MP1 Antibody (aa20-180, DY650) - LS-C143569 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LAMTOR3 / MP1 Antibody (aa20-180, DY550) - LS-C143572 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LAMTOR3 / MP1 Antibody (aa1-124, Biotin) - LS-C299500 from LifeSpan Bioscience Prices $415.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-LAMTOR3 / MP1 Antibody (aa1-124, FITC) - LS-C303588 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-LAMTOR3 / MP1 Antibody (aa1-88) - LS-C308887 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-LAMTOR3 / MP1 Antibody (aa1-124) - LS-C295395 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-LAMTOR3 / MP1 Antibody (aa13-62) - LS-C170333 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-LAMTOR3 / MP1 Antibody - LS-C332202 from LifeSpan Bioscience Prices $305.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-LAMTOR3 / MP1 Antibody (C-Terminus, clone Y130) - LS-C49511 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone Y130

Anti-LAMTOR3 / MP1 Antibody (aa1-124) - LS-C186187 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LAMTOR3 / MP1 Antibody - LS-C180100 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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