LAMTOR3

Gene Symbol	LAMTOR3
Entrez Gene	8649
Alt Symbol	MAP2K1IP1, MAPBP, MAPKSP1, MP1, PRO0633, Ragulator3
Species	Human
Gene Type	protein-coding
Description	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Other Description	MAPK scaffold protein 1|MEK binding partner 1|late endosomal/lysosomal adaptor and MAPK and MTOR activator 3|mitogen-activated protein kinase kinase 1 interacting protein 1|mitogen-activated protein kinase scaffold protein 1|ragulator complex protein LAMTOR3
Swissprots	Q9H364 Q9UHA4 J3KMX4 B2R4A1
Accessions	CAT04668 EAX06112 EAX06113 Q9UHA4 AF130115 AAG35540 AF201947 AAF17239 AF305816 AAK55519 AK022313 AK223311 BAD97031 AK311755 BAG34698 AL544981 BC005340 BC026245 AAH26245 BC110402 BI562630 DA300823 DQ893108 ABM84034 DQ896381 ABM87380 NM_001243736 NP_001230665 NM_021970 NP_068805 NR_024170
Function	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22980980}.
Subcellular Location	Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MAP2K1IP1 full length protein - ab102022 from Abcam Category Protein Source E. coli Species Human

LAMTOR3 / MP1 Antibody Blocking Peptide - LS-E22075 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MP1/MAP2K1IP1 Recombinant Protein - H00008649-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MP1/MAP2K1IP1 Partial Recombinant Protein - H00008649-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human MP1/MAP2K1IP1 Protein - NBP1-50889 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

MAPKSP1-Antibody-N-term-Blocking-Peptide - BP17561a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MP1 Protein - GTX111032-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

MAPKSP1 Protein (OPPA02571) - OPPA02571 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human MAPKSP1 protein - orb168779 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

MAPKSP1 protein (His tag) - 80R-1566 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

Human MAPKSP1 Protein - abx068043 from Abbexa Category Protein Source E.coli Species Human

MAP2K1IP1 (1-124, His-tag) - AR09745PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

MAP2K1IP1 (1-124, His-tag) - AR09745PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

MAP2K1IP1 - H00008649-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MAP2K1IP1 - H00008649-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MAP2K1IP1 - H00008649-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MAP2K1IP1 - H00008649-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MAPKSP1, 1-124aa, Human, His tag, E.coli - 01-1755-SP1 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

Mitogen-Activated Protein Kinase Scaffold Protein 1, MAPKSP1, Human, Recombinant - 19-CE21 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

LAMTOR3 Peptide - 7713P from ProSci Category Peptide Species Human

MAPKSP1 fusion protein - Ag2534 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

MAPKSP1 fusion protein - Ag18319 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

MAPKSP1 Human - PRPS-041 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 25 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human MAPKSP1 Protein - BP001331-CE21 from Syd Labs Category Protein Prices $180.00, $528.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human MAPKSP1 Protein - BP001331-PRO-034 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 25 µg, 1 mg Source E. coli-derived. Species Human

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