LAMTOR3

Gene Symbol	LAMTOR3
Entrez Gene	8649
Alt Symbol	MAP2K1IP1, MAPBP, MAPKSP1, MP1, PRO0633, Ragulator3
Species	Human
Gene Type	protein-coding
Description	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Other Description	MAPK scaffold protein 1|MEK binding partner 1|late endosomal/lysosomal adaptor and MAPK and MTOR activator 3|mitogen-activated protein kinase kinase 1 interacting protein 1|mitogen-activated protein kinase scaffold protein 1|ragulator complex protein LAMTOR3
Swissprots	Q9H364 Q9UHA4 J3KMX4 B2R4A1
Accessions	CAT04668 EAX06112 EAX06113 Q9UHA4 AF130115 AAG35540 AF201947 AAF17239 AF305816 AAK55519 AK022313 AK223311 BAD97031 AK311755 BAG34698 AL544981 BC005340 BC026245 AAH26245 BC110402 BI562630 DA300823 DQ893108 ABM84034 DQ896381 ABM87380 NM_001243736 NP_001230665 NM_021970 NP_068805 NR_024170
Function	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22980980}.
Subcellular Location	Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Top Pathways	MAPK signaling pathway

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• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MAP2K1-Over-expression-Lysate - LY10172a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

LAMTOR3 overexpression lysate - LY411845 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

MAPKSP1 293 Cell Lysate - 405897 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

MP1/MAP2K1IP1 Overexpression Lysate (Native) - NBL1-12846 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

MAPKSP1 Over-expression Lysate Product - GWB-31170B from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human LAMTOR3 Knockdown Stable Cell Line - CSC-DC008537 from Creative biogene Category Cell Line Species Human

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