LAMTOR3

Gene Symbol LAMTOR3
Entrez Gene 8649
Alt Symbol MAP2K1IP1, MAPBP, MAPKSP1, MP1, PRO0633, Ragulator3
Species Human
Gene Type protein-coding
Description late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Other Description MAPK scaffold protein 1|MEK binding partner 1|late endosomal/lysosomal adaptor and MAPK and MTOR activator 3|mitogen-activated protein kinase kinase 1 interacting protein 1|mitogen-activated protein kinase scaffold protein 1|ragulator complex protein LAMTOR3
Swissprots Q9H364 Q9UHA4 J3KMX4 B2R4A1
Accessions CAT04668 EAX06112 EAX06113 Q9UHA4 AF130115 AAG35540 AF201947 AAF17239 AF305816 AAK55519 AK022313 AK223311 BAD97031 AK311755 BAG34698 AL544981 BC005340 BC026245 AAH26245 BC110402 BI562630 DA300823 DQ893108 ABM84034 DQ896381 ABM87380 NM_001243736 NP_001230665 NM_021970 NP_068805 NR_024170
Function As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22980980}.
Subcellular Location Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Top Pathways MAPK signaling pathway

MP1 CRISPR/Cas9 KO Plasmid (h) - sc-406088 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MP1 HDR Plasmid (h) - sc-406088-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MP1 Double Nickase Plasmid (h) - sc-406088-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MP1 Double Nickase Plasmid (h2) - sc-406088-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MP1 CRISPR Activation Plasmid (h) - sc-406088-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MP1 CRISPR Activation Plasmid (h2) - sc-406088-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MP1 Lentiviral Activation Particles (h) - sc-406088-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MP1 Lentiviral Activation Particles (h2) - sc-406088-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MP1 siRNA (h) - sc-40746 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MP1 shRNA Plasmid (h) - sc-40746-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MP1 shRNA (h) Lentiviral Particles - sc-40746-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MP1/MAP2K1IP1 RNAi - H00008649-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU106201 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN13024 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13024 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

LAMTOR3 siRNA (Human) - CRH5687 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human LAMTOR3 (NM_021970.3) - SHH328387 from Creative biogene

Category siRNA
Species Reactivities Human

LAMTOR3 shRNA Plasmid (Human) - CHH5687 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LAMTOR3 miRNA 3'UTR clone - MiUTR4H-TG05361 from Creative biogene

Species Reactivities Human
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