| Gene Symbol |
LAMTOR3
|
| Entrez Gene |
8649
|
| Alt Symbol |
MAP2K1IP1, MAPBP, MAPKSP1, MP1, PRO0633, Ragulator3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
|
| Other Description |
MAPK scaffold protein 1|MEK binding partner 1|late endosomal/lysosomal adaptor and MAPK and MTOR activator 3|mitogen-activated protein kinase kinase 1 interacting protein 1|mitogen-activated protein kinase scaffold protein 1|ragulator complex protein LAMTOR3
|
| Swissprots |
Q9H364 Q9UHA4 J3KMX4 B2R4A1
|
| Accessions |
CAT04668 EAX06112 EAX06113 Q9UHA4 AF130115 AAG35540 AF201947 AAF17239 AF305816 AAK55519 AK022313 AK223311 BAD97031 AK311755 BAG34698 AL544981 BC005340 BC026245 AAH26245 BC110402 BI562630 DA300823 DQ893108 ABM84034 DQ896381 ABM87380 NM_001243736 NP_001230665 NM_021970 NP_068805 NR_024170
|
| Function |
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22980980}.
|
| Subcellular Location |
Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
|
| Top Pathways |
MAPK signaling pathway
|