| Gene Symbol |
HSD3B1
|
| Entrez Gene |
3283
|
| Alt Symbol |
3BETAHSD, HSD3B, HSDB3, HSDB3A, I, SDR11E1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
|
| Other Description |
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1|3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I|3-beta-HSD I|3-beta-hydroxy-5-ene steroid dehydrogenase|3-beta-hydroxy-Delta(5)-steroid dehydrogenase|delta-5-3-ketosteroid isomerase|hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 1|progesterone reductase|short chain dehydrogenase/reductase family 11E, member 1|steroid Delta-isomerase|trophoblast antigen FDO161G
|
| Swissprots |
P14060 A8K691 Q8IV65 Q14545
|
| Accessions |
AAA36001 AAA51662 AAA51831 CBH19320 EAW56703 EAW56704 P14060 AK291556 BAF84245 AL544564 BC031999 AAH31999 DQ891161 ABM82087 DQ894342 ABM85268 M27137 AAA36015 M35493 AAA51538 S45679 AAB23543 X53321 CAA37408 X55997 CAA39469 XM_011541314 XP_011539616 NM_000862 NP_000853
|
| Function |
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17- alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone. {ECO:0000269|PubMed:1401999, ECO:0000269|PubMed:2139411}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
|
| Tissue Specificity |
Placenta and skin. Predominantly expressed in mammary gland tissue.
|
| Top Pathways |
Steroid hormone biosynthesis, Ovarian steroidogenesis
|
![Western Blot: HSD3B1 Overexpression Lysate (Adult Normal) [NBL1-11732] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HSD3B1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1068_HSD3B1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11732-img0002.jpg)