HSD3B1

Gene Symbol HSD3B1
Entrez Gene 3283
Alt Symbol 3BETAHSD, HSD3B, HSDB3, HSDB3A, I, SDR11E1
Species Human
Gene Type protein-coding
Description hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Other Description 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1|3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I|3-beta-HSD I|3-beta-hydroxy-5-ene steroid dehydrogenase|3-beta-hydroxy-Delta(5)-steroid dehydrogenase|delta-5-3-ketosteroid isomerase|hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 1|progesterone reductase|short chain dehydrogenase/reductase family 11E, member 1|steroid Delta-isomerase|trophoblast antigen FDO161G
Swissprots P14060 A8K691 Q8IV65 Q14545
Accessions AAA36001 AAA51662 AAA51831 CBH19320 EAW56703 EAW56704 P14060 AK291556 BAF84245 AL544564 BC031999 AAH31999 DQ891161 ABM82087 DQ894342 ABM85268 M27137 AAA36015 M35493 AAA51538 S45679 AAB23543 X53321 CAA37408 X55997 CAA39469 XM_011541314 XP_011539616 NM_000862 NP_000853
Function 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17- alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone. {ECO:0000269|PubMed:1401999, ECO:0000269|PubMed:2139411}.
Subcellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Tissue Specificity Placenta and skin. Predominantly expressed in mammary gland tissue.
Top Pathways Steroid hormone biosynthesis, Ovarian steroidogenesis

Human HSD3B1 full length protein - ab158702 from Abcam

Category Protein
Source Wheat germ
Species Human
ab158702 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human HSD3B1 peptide - ab48064 from Abcam

Category Peptide
Species Human

HSD3B1 Antibody Blocking Peptide - LS-E3409 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

HSD3B1 Antibody Blocking Peptide - LS-E26082 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

HSD3B1 Antibody Blocking Peptide - LS-E15386 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human HSD3B1 Protein - H00003283-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

HSD3B1-Antibody-N-term-Blocking-Peptide - BP14585a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

HSD3B1 blocking peptide - GTX89377-PEP from GeneTex

Category Peptide
Prices $239.00
Sizes 100 μg
Species Human

HSD3B1 Blocking Peptide - 33R-9099 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

HSD3B1 Peptide - AC21-0910-P from Abcore

Category Peptide
Prices $160.00
Sizes 100 µg

HSD3B1 Peptide - 45-749P from ProSci

Category Peptide
Prices $175.00
Sizes 100 µg
Species Human

Recombinant I/6 autoantigen - CSB-YP634619TQV CSB-EP634619TQV CSB-BP634619TQV CSB-MP634619TQV from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Trypanosoma

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1), Recombinant Protein - MBS718727 from MyBioSource

Category Protein
Prices $1,375.00, $1,835.00
Sizes 1 mg (E Coli Derived), 1 mg (Yeast Derived)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

HSD3B1 Protein - abx164512 from Abbexa

Category Protein
Species Human, Mouse, Rat

3-beta-HSD1 / HSD3B1 - TP304497 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
3-beta-HSD1 / HSD3B1

HSD3B1, Peptide - MBS425353 from MyBioSource

Category Peptide
Prices $175.00
Sizes 100 µg
Species Human

HSD3B1 Protein - NBP2-33386PEP from Novus Biologicals

Category Protein
Prices $209.00
Sizes 100 µl
Species Human

HSD3B1 Recombinant Protein Antigen - NBP2-33385PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

Peptide I - A27015 from Creative Peptides

Category Peptide

HSD3B1 Peptide, Human - M34GP07286H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1), Recombinant Protein - MBS7016792 from MyBioSource

Category Protein
Prices $1,180.00, $2,165.00, $3,375.00
Sizes 10 µg, 50 µg, 100 µg
Source Cell Free Expression
Species Human

I/6 autoantigen, Recombinant Protein - MBS1321196 from MyBioSource

Category Protein
Prices $990.00, $990.00, $1,220.00, $1,220.00, $1,515.00, $1,515.00, $1,980.00, $1,980.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Trypanosoma

Major pollen allergen Bet v 1-F/I (BETV1F), Recombinant Protein - MBS1177164 from MyBioSource

Category Protein
Prices $900.00, $900.00, $1,125.00, $1,125.00, $1,330.00, $1,330.00, $1,785.00, $1,785.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell

Protein I (N), Recombinant Protein - MBS1454354 from MyBioSource

Category Protein
Prices $955.00, $955.00, $1,180.00, $1,180.00, $1,425.00, $1,425.00, $1,890.00, $1,890.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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