HSD3B1

Gene Symbol	HSD3B1
Entrez Gene	3283
Alt Symbol	3BETAHSD, HSD3B, HSDB3, HSDB3A, I, SDR11E1
Species	Human
Gene Type	protein-coding
Description	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Other Description	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1|3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I|3-beta-HSD I|3-beta-hydroxy-5-ene steroid dehydrogenase|3-beta-hydroxy-Delta(5)-steroid dehydrogenase|delta-5-3-ketosteroid isomerase|hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 1|progesterone reductase|short chain dehydrogenase/reductase family 11E, member 1|steroid Delta-isomerase|trophoblast antigen FDO161G
Swissprots	P14060 A8K691 Q8IV65 Q14545
Accessions	AAA36001 AAA51662 AAA51831 CBH19320 EAW56703 EAW56704 P14060 AK291556 BAF84245 AL544564 BC031999 AAH31999 DQ891161 ABM82087 DQ894342 ABM85268 M27137 AAA36015 M35493 AAA51538 S45679 AAB23543 X53321 CAA37408 X55997 CAA39469 XM_011541314 XP_011539616 NM_000862 NP_000853
Function	3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17- alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone. {ECO:0000269|PubMed:1401999, ECO:0000269|PubMed:2139411}.
Subcellular Location	Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Tissue Specificity	Placenta and skin. Predominantly expressed in mammary gland tissue.
Top Pathways	Steroid hormone biosynthesis, Ovarian steroidogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-HSD3B1-cDNA-Clone - DC06314 from Abgent, a WuXi AppTec company Prices $503.55 Sizes 10 µg Species Human Accession BC031999

HSD3B1 - MBS1267934 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC031999

Human HSD3B1 ORF Clone(NM_000862.2) - CDCL166539 from Creative Biomart Species Human Accession NM_000862.2

Human HSD3B1 ORF Clone(NM_000862.2) - CDCR337869 from Creative Biomart Species Human Accession NM_000862.2

Human HSD3B1 ORF Clone(NM_000862.2) - CDCR337870 from Creative Biomart Species Human Accession NM_000862.2

Human HSD3B1 ORF Clone(NM_000862.2) - CDCR337871 from Creative Biomart Species Human Accession NM_000862.2

Human HSD3B1 Gene cDNA Clone (full-length ORF Clone) - HG14410-G from Sino Biological Species Human Accession BC031999

Human HSD3B1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG14410-CY from Sino Biological Species Human

Human HSD3B1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG14410-NF from Sino Biological Species Human

Human HSD3B1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14410-CF from Sino Biological Species Human

Human HSD3B1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG14410-NM from Sino Biological Species Human

Human HSD3B1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-His-tagged - HG14410-NH from Sino Biological Species Human Accession BC031999

Human HSD3B1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG14410-CM from Sino Biological Species Human

Human HSD3B1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG14410-ANG from Sino Biological Species Human

Human HSD3B1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG14410-NY from Sino Biological Species Human

Human HSD3B1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG14410-ACG from Sino Biological Species Human

Human HSD3B1 Gene ORF cDNA clone expression plasmid, C-His tag - HG14410-CH from Sino Biological Species Human

Human HSD3B1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG14410-ACR from Sino Biological Species Human

Human HSD3B1 Gene ORF cDNA clone expression plasmid - HG14410-UT from Sino Biological Species Human

Human HSD3B1 ORF clone (NM_000862.2) - CDCL118565 from Creative biogene Species Human

Human HSD3B1 ORF Clone (BC031999) - CDCS405958 from Creative biogene Species Human Accession P14060

Human HSD3B1 ORF clone (BC031999) - CDCB159095 from Creative biogene Species Human

Human HSD3B1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG14410-ANR from Sino Biological Species Human

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