| Gene Symbol | SP3 |
|---|---|
| Entrez Gene | 6670 |
| Alt Symbol | SPR2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Sp3 transcription factor |
| Other Description | GC-binding transcription factor Sp3|specificity protein 3|transcription factor Sp3 |
| Swissprots | Q69B26 B4E2B7 A0AVL9 Q8TD56 Q8WWU4 Q02447 Q69B27 Q9BQR1 |
| Accessions | AAM12875 AAP03059 EAX11152 EAX11153 EAX11154 EAX11155 Q02447 AA706229 AB209334 BAD92571 AJ310752 CAC34575 AJ430844 CAD23619 AK304199 BAG65079 AW204666 AW295583 AY070137 AAL58086 AY441957 AAR30505 AY441958 AAR30506 BC042945 AAH42945 BC126414 AAI26415 BC143928 AAI43929 BQ010796 BX648857 CR749323 CAH18178 HQ258632 ADR83384 M97191 AAA36630 X68560 CAA48562 NM_001017371 NP_001017371 NM_001172712 NP_001166183 NM_003111 NP_003102 |
| Function | Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone- induction and house-keeping. {ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11812829, ECO:0000269|PubMed:12419227, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:15247228, ECO:0000269|PubMed:15494207, ECO:0000269|PubMed:15554904, ECO:0000269|PubMed:16781829, ECO:0000269|PubMed:17548428, ECO:0000269|PubMed:18187045, ECO:0000269|PubMed:18617891, ECO:0000269|PubMed:9278495}. |
| Subcellular Location | Nucleus. Nucleus, PML body. Note=Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies. |
| Tissue Specificity | Ubiquitously expressed. |