SP3

Gene Symbol SP3
Entrez Gene 6670
Alt Symbol SPR2
Species Human
Gene Type protein-coding
Description Sp3 transcription factor
Other Description GC-binding transcription factor Sp3|specificity protein 3|transcription factor Sp3
Swissprots Q69B26 B4E2B7 A0AVL9 Q8TD56 Q8WWU4 Q02447 Q69B27 Q9BQR1
Accessions AAM12875 AAP03059 EAX11152 EAX11153 EAX11154 EAX11155 Q02447 AA706229 AB209334 BAD92571 AJ310752 CAC34575 AJ430844 CAD23619 AK304199 BAG65079 AW204666 AW295583 AY070137 AAL58086 AY441957 AAR30505 AY441958 AAR30506 BC042945 AAH42945 BC126414 AAI26415 BC143928 AAI43929 BQ010796 BX648857 CR749323 CAH18178 HQ258632 ADR83384 M97191 AAA36630 X68560 CAA48562 NM_001017371 NP_001017371 NM_001172712 NP_001166183 NM_003111 NP_003102
Function Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone- induction and house-keeping. {ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11812829, ECO:0000269|PubMed:12419227, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:15247228, ECO:0000269|PubMed:15494207, ECO:0000269|PubMed:15554904, ECO:0000269|PubMed:16781829, ECO:0000269|PubMed:17548428, ECO:0000269|PubMed:18187045, ECO:0000269|PubMed:18617891, ECO:0000269|PubMed:9278495}.
Subcellular Location Nucleus. Nucleus, PML body. Note=Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies.
Tissue Specificity Ubiquitously expressed.

Sp3 CRISPR/Cas9 KO Plasmid (h) - sc-401167 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sp3 HDR Plasmid (h) - sc-401167-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sp3 Double Nickase Plasmid (h) - sc-401167-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sp3 Double Nickase Plasmid (h2) - sc-401167-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sp3 CRISPR Activation Plasmid (h) - sc-401167-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sp3 CRISPR Activation Plasmid (h2) - sc-401167-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sp3 Lentiviral Activation Particles (h) - sc-401167-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sp3 Lentiviral Activation Particles (h2) - sc-401167-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sp3 siRNA (h) - sc-29490 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Sp3 shRNA Plasmid (h) - sc-29490-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Sp3 shRNA (h) Lentiviral Particles - sc-29490-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Sp3 RNAi - H00006670-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU024031 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20369 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20369 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SP3 siRNA (Human) - CRH4548 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Sp3 RNAi - H00006670-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SP3 - MBS8224728 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SP3 (NM_003111.4) - SHH415604 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SP3(NM_003111.4) - SHL018210 from Creative biogene

Category siRNA
Species Reactivities Human

Human SP3 siRNA - orb265050 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SP3 shRNA Plasmid (Human) - CHH4548 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SP3 miRNA 3'UTR clone - MiUTR1H-09779 from Creative biogene

Species Reactivities Human
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