SP3

Gene Symbol	SP3
Entrez Gene	6670
Alt Symbol	SPR2
Species	Human
Gene Type	protein-coding
Description	Sp3 transcription factor
Other Description	GC-binding transcription factor Sp3|specificity protein 3|transcription factor Sp3
Swissprots	Q69B26 B4E2B7 A0AVL9 Q8TD56 Q8WWU4 Q02447 Q69B27 Q9BQR1
Accessions	AAM12875 AAP03059 EAX11152 EAX11153 EAX11154 EAX11155 Q02447 AA706229 AB209334 BAD92571 AJ310752 CAC34575 AJ430844 CAD23619 AK304199 BAG65079 AW204666 AW295583 AY070137 AAL58086 AY441957 AAR30505 AY441958 AAR30506 BC042945 AAH42945 BC126414 AAI26415 BC143928 AAI43929 BQ010796 BX648857 CR749323 CAH18178 HQ258632 ADR83384 M97191 AAA36630 X68560 CAA48562 NM_001017371 NP_001017371 NM_001172712 NP_001166183 NM_003111 NP_003102
Function	Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone- induction and house-keeping. {ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11812829, ECO:0000269|PubMed:12419227, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:15247228, ECO:0000269|PubMed:15494207, ECO:0000269|PubMed:15554904, ECO:0000269|PubMed:16781829, ECO:0000269|PubMed:17548428, ECO:0000269|PubMed:18187045, ECO:0000269|PubMed:18617891, ECO:0000269|PubMed:9278495}.
Subcellular Location	Nucleus. Nucleus, PML body. Note=Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies.
Tissue Specificity	Ubiquitously expressed.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SP3 Antibody Blocking Peptide - LS-E3261 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SP3 Antibody Blocking Peptide - LS-E11757 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SP3-Antibody-Center-Blocking-Peptide - BP14413c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SP3 Blocking Peptide - 33R-10976 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

SP3 / SPR-2 - H00006670-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

SP3 / SPR-2 - H00006670-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SP3 / SPR-2 - H00006670-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SP3 fusion protein - ag17881 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

SP3 fusion protein - Ag17800 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Sp3 Transcription Factor, FLAG-tagged - SP3-2094H from Creative Biomart Category Protein Source SL2.

Recombinant Human SP3 - SP3-31436TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human SP3, MYC/DDK-tagged - SP3-104H from Creative Biomart Category Protein Source HEK293 cells Species Human

SP3/4 Blocking Peptide - CBP3492 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Chicken, Zebrafish

Sp3/4 (G659) Peptide - BS2030P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Sp3 Blocking Peptide - 3887BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

SP3 / SPR-2 (transcript variant 1) - TP322027 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Sp3, Peptide - MBS843666 from MyBioSource Category Peptide Prices $165.00 Sizes 50 µg

Sp3, Peptide - MBS443050 from MyBioSource Category Peptide Prices $125.00 Sizes 100 µg

SP3 fusion protein - Ag25082 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SP3/4 Blocking Peptide - abx162354 from Abbexa Category Peptide Species Human, Mouse, Chicken, Zebrafish

SP3 fusion protein - Ag25103 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET30a Species Human

SP3 Peptide, Human - M34GP14932H from Creative Peptides Category Peptide Source Synthetic. Species Human

SP3/4 Peptide - orb224378 from Biorbyt Category Peptide Species Human, Mouse, Zebrafish, Cat

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