SP3

Gene Symbol SP3
Entrez Gene 6670
Alt Symbol SPR2
Species Human
Gene Type protein-coding
Description Sp3 transcription factor
Other Description GC-binding transcription factor Sp3|specificity protein 3|transcription factor Sp3
Swissprots Q69B26 B4E2B7 A0AVL9 Q8TD56 Q8WWU4 Q02447 Q69B27 Q9BQR1
Accessions AAM12875 AAP03059 EAX11152 EAX11153 EAX11154 EAX11155 Q02447 AA706229 AB209334 BAD92571 AJ310752 CAC34575 AJ430844 CAD23619 AK304199 BAG65079 AW204666 AW295583 AY070137 AAL58086 AY441957 AAR30505 AY441958 AAR30506 BC042945 AAH42945 BC126414 AAI26415 BC143928 AAI43929 BQ010796 BX648857 CR749323 CAH18178 HQ258632 ADR83384 M97191 AAA36630 X68560 CAA48562 NM_001017371 NP_001017371 NM_001172712 NP_001166183 NM_003111 NP_003102
Function Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone- induction and house-keeping. {ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11812829, ECO:0000269|PubMed:12419227, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:15247228, ECO:0000269|PubMed:15494207, ECO:0000269|PubMed:15554904, ECO:0000269|PubMed:16781829, ECO:0000269|PubMed:17548428, ECO:0000269|PubMed:18187045, ECO:0000269|PubMed:18617891, ECO:0000269|PubMed:9278495}.
Subcellular Location Nucleus. Nucleus, PML body. Note=Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies.
Tissue Specificity Ubiquitously expressed.

Sp3 (D-6) - sc-365038 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Sp3 (D-6): sc-365038. Western blot analysis of Sp3 expression in K-562 whole cell lysate.

Sp3 (D-20) - sc-644 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Sp3 (D-20): sc-644. Western blot analysis of Sp3 expression in KNRK nuclear extract.

Sp3 (F-11) - sc-55479 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Sp3 (F-11): sc-55479. Western blot analysis of Sp3 expression in Jurkat (A) and K-562 (B) nuclear extracts.

Sp3 (F-7) - sc-28305 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Sp3 (F-7): sc-28305. Immunoperoxidase staining of formalin fixed, paraffin-embedded human endometrium tissue showing nuclear staining of endometrial stroma and myometrium. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Sp3 (G-7) - sc-365220 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Sp3 (G-7): sc-365220. Western blot analysis of Sp3 expression in Jurkat nuclear extract.

Sp3 (8) - sc-136479 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Sp3 (8): sc-136479. Western blot analysis of Sp3 expression in K-562 whole cell lysate.

Sp3 (H-225) - sc-13018 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Sp4 (V-20): sc-645. ChIP analysis of Sp4 recruitment to genomic amplicons. Four (1-4) different human genomic Sp-1 and two control amplicons (5,6) were analyzed by quantitative PCR (primer sequences available in on-line supplemental data). Data generated in collaboration with Drs. N. Trinklein and R. Myers, Stanford University (ENCODE Project).

Anti-SP3 antibody - ab85065 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human kidney tissue using 1/200 ab85065. Note nuclear staining of cells.

Anti-SP3 antibody - ab72594 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SP3 antibody (ab72594) at 1/500 dilutionLane 1 : extracts from Jurkat cells Lane 2 : extracts from Jurkat cells, with 10 ug of the immunising peptide.Lysates/proteins at 30 µg per lane.

Anti-SP3 antibody - ab87091 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SP3 antibody (ab87091) at 1 µg/ml + Fetal muscle lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-SP3 antibody - ab186400 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SP3 antibody (ab186400) at 1 µg/ml + RPMI-8226 cell lysate

Anti-SP3 antibody [EPR6806] - ab129099 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6806
All lanes : Anti-SP3 antibody [EPR6806] (ab129099) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : HeLa cell lysateLane 3 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-SP3 Antibody (aa287-336) IHC-plus™ - LS-B3502 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SP3 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3502 concentration 5 ug/ml.

Anti-SP3 Antibody IHC-plus™ - LS-B11770 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Mouse Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-SP3 Antibody (aa731-781) - LS-C289219 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Sp3 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-Sp3 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

Anti-SP3 Antibody (aa731-781) - LS-C286926 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Mouse Sp3 by Immunohistochemistry. Sample: FFPE section of mouse teratoma. Antibody: Affinity purified rabbit anti-Sp3 used at a dilution of 1:100.

Anti-SP3 Antibody (C-Terminus) IHC-plus™ - LS-B1648 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-SP3 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1648 dilution 1:50.

Anti-SP3 Antibody (aa1-74) - LS-C311912 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SP3 antibody used in IHC (Formalin-fixed paraffin-embedded sections).

Anti-SP3 Antibody (aa239-653) - LS-C10311 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-SP3 Antibody (C-Terminus) - LS-C51728 from LifeSpan Bioscience

Prices $295.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SP3 Antibody (clone 3D4) - LS-C198249 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D4

Anti-SP3 Antibody (N-Terminus) - LS-C203220 from LifeSpan Bioscience

Prices $245.00
Sizes 40 µg
Host Rabbit
Clonality Polyclonal

Anti-SP3 Antibody (aa292-321, AP) - LS-C270067 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SP3 Antibody (aa292-321, APC) - LS-C270068 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SP3 Antibody (aa292-321, Biotin) - LS-C270069 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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