| Gene Symbol |
PNKP
|
| Entrez Gene |
11284
|
| Alt Symbol |
AOA4, EIEE10, MCSZ, PNK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polynucleotide kinase 3'-phosphatase
|
| Other Description |
DNA 5'-kinase/3'-phosphatase|Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP)|bifunctional polynucleotide phosphatase/kinase
|
| Swissprots |
Q9BUL2 Q96T60 Q9UKU8 Q9P1V2 Q9UNI0 Q9UNF8
|
| Accessions |
AAF44716 AAK57340 AAM82170 EAW52565 EAW52566 EAW52567 Q96T60 AA640353 AF120499 AAD47379 AF125807 AAD50639 AF126486 AAD51135 BC002519 AAH02519 BC009339 BC013034 BC033822 AAH33822 BU541073 DQ890806 ABM81732 DQ893961 ABM84887 NM_007254 NP_009185
|
| Function |
Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. {ECO:0000269|PubMed:10446192}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10446193}.
|
| Tissue Specificity |
Expressed in many tissues with highest expression in spleen and testis, and lowest expression in small intestine (PubMed:10446192). Expressed in higher amount in pancreas, heart and kidney and at lower levels in brain, lung and liver (PubMed:10446193). {ECO:0000269|PubMed:10446192, ECO:0000269|PubMed:10446193}.
|