PNKP

Gene Symbol PNKP
Entrez Gene 11284
Alt Symbol AOA4, EIEE10, MCSZ, PNK
Species Human
Gene Type protein-coding
Description polynucleotide kinase 3'-phosphatase
Other Description DNA 5'-kinase/3'-phosphatase|Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP)|bifunctional polynucleotide phosphatase/kinase
Swissprots Q9BUL2 Q96T60 Q9UKU8 Q9P1V2 Q9UNI0 Q9UNF8
Accessions AAF44716 AAK57340 AAM82170 EAW52565 EAW52566 EAW52567 Q96T60 AA640353 AF120499 AAD47379 AF125807 AAD50639 AF126486 AAD51135 BC002519 AAH02519 BC009339 BC013034 BC033822 AAH33822 BU541073 DQ890806 ABM81732 DQ893961 ABM84887 NM_007254 NP_009185
Function Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. {ECO:0000269|PubMed:10446192}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10446193}.
Tissue Specificity Expressed in many tissues with highest expression in spleen and testis, and lowest expression in small intestine (PubMed:10446192). Expressed in higher amount in pancreas, heart and kidney and at lower levels in brain, lung and liver (PubMed:10446193). {ECO:0000269|PubMed:10446192, ECO:0000269|PubMed:10446193}.

PNKP-Over-expression-Lysate - LY10657a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag PNKP (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PNKP gene

PNKP overexpression lysate - LY416093 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

PNK Overexpression Lysate (Denatured) - H00011284-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
PNKP transfected lysate.

PNK (h): 293T Lysate - sc-115119 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

PNK Overexpression Lysate (Native) - NBP2-10374 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: PNK Overexpression Lysate (Adult Normal) [NBP2-10374] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PNK.

Panoply™ Human PNKP Knockdown Stable Cell Line - CSC-DC012016 from Creative biogene

Category Cell Line
Species Human
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