PNKP

Gene Symbol	PNKP
Entrez Gene	11284
Alt Symbol	AOA4, EIEE10, MCSZ, PNK
Species	Human
Gene Type	protein-coding
Description	polynucleotide kinase 3'-phosphatase
Other Description	DNA 5'-kinase/3'-phosphatase|Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP)|bifunctional polynucleotide phosphatase/kinase
Swissprots	Q9BUL2 Q96T60 Q9UKU8 Q9P1V2 Q9UNI0 Q9UNF8
Accessions	AAF44716 AAK57340 AAM82170 EAW52565 EAW52566 EAW52567 Q96T60 AA640353 AF120499 AAD47379 AF125807 AAD50639 AF126486 AAD51135 BC002519 AAH02519 BC009339 BC013034 BC033822 AAH33822 BU541073 DQ890806 ABM81732 DQ893961 ABM84887 NM_007254 NP_009185
Function	Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. {ECO:0000269|PubMed:10446192}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:10446193}.
Tissue Specificity	Expressed in many tissues with highest expression in spleen and testis, and lowest expression in small intestine (PubMed:10446192). Expressed in higher amount in pancreas, heart and kidney and at lower levels in brain, lung and liver (PubMed:10446193). {ECO:0000269|PubMed:10446192, ECO:0000269|PubMed:10446193}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PNK full length protein - ab131925 from Abcam Category Protein Source Wheat germ Species Human

Human PNK peptide - ab22956 from Abcam Category Peptide Species Human

Human PNK protein fragment - ab161404 from Abcam Category Protein Source Wheat germ Species Human

PNKP Antibody Blocking Peptide - LS-E2985 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PNKP Antibody Blocking Peptide - LS-E25387 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PNKP Antibody Blocking Peptide - LS-E18808 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PNKP Antibody Blocking Peptide - LS-E18807 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PNK Protein - H00011284-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PNK Protein - H00011284-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PNKP-Antibody-N-term-Blocking-peptide - BP14116a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PNK blocking peptide - GTX89883-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Human PNKP protein - orb244931 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

PNKP Blocking Peptide - 33R-1356 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PNKP Blocking Peptide - 33R-6026 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PNK Peptide - AC21-0215-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PNKP - H00011284-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PNKP - H00011284-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PNKP - H00011284-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PNKP - H00011284-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PNKP Peptide - 45-115P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

PNKP fusion protein - Ag4703 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PNKP fusion protein - Ag4421 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Bifunctional polynucleotide phosphatase/kinase(PNKP) - CSB-YP857031HU CSB-BP857031HU CSB-MP857031HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Bifunctional polynucleotide phosphatase/kinase - CSB-EP857031HU from Cusabio Category Protein Source E.coli Species Human

PNKP - TP307551 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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