| Gene Symbol |
MMEL1
|
| Entrez Gene |
79258
|
| Alt Symbol |
MMEL2, NEP2, NEPII, NL1, NL2, SEP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
membrane metallo-endopeptidase-like 1
|
| Other Description |
NEP2(m)|membrane metallo-endopeptidase-like 2|neprilysin II|neprilysin-2|soluble secreted endopeptidase|zinc metallopeptidase
|
| Swissprots |
Q495T6 B9DI79 Q5SZS6 Q96PH9 Q495T7 Q495T8
|
| Accessions |
CAC09978 EAW56080 EAW56081 EAW56082 Q495T6 AF336981 AAL08942 AK093058 BAG52644 BC101027 AAI01028 BC101028 AAI01029 BC101029 AAI01030 BC101030 AAI01031 DB089501 XM_011542115 XP_011540417 XM_011542116 XP_011540418 XM_011542117 XP_011540419 XM_011542118 XP_011540420 XM_011542119 XP_011540421 XM_011542120 XP_011540422 XM_011542121 XP_011540423 XM_011542122 XP_011540424 XM_011542123 XP_011540425 XM_011542124 XP_011540426 XM_011542125 XP_011540427 XM_011546399 XP_011544701 XM_011546400 XP_011544702 XM_011546401 XP_011544703 XM_011546402 XP_011544704 XM_011546403 XP_011544705 XM_011546404 XP_011544706 XM_011546405 XP_011544707 XM_011546406 XP_011544708 XM_011546407 XP_011544709 XM_011546408 XP_011544710 XM_011546409 XP_011544711 XM_011546410 XP_011544712 XR_946752 XR_946753 XR_946754 XR_951571 XR_951572 XR_951573 NM_033467 NP_258428
|
| Function |
Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form produced by proteollytic cleavage also exists. {ECO:0000250}.
|
| Tissue Specificity |
Predominantly expressed in testis. Weakly expressed in brain, kidney and heart. {ECO:0000269|PubMed:11560781}.
|