MMEL1

Gene Symbol MMEL1
Entrez Gene 79258
Alt Symbol MMEL2, NEP2, NEPII, NL1, NL2, SEP
Species Human
Gene Type protein-coding
Description membrane metallo-endopeptidase-like 1
Other Description NEP2(m)|membrane metallo-endopeptidase-like 2|neprilysin II|neprilysin-2|soluble secreted endopeptidase|zinc metallopeptidase
Swissprots Q495T6 B9DI79 Q5SZS6 Q96PH9 Q495T7 Q495T8
Accessions CAC09978 EAW56080 EAW56081 EAW56082 Q495T6 AF336981 AAL08942 AK093058 BAG52644 BC101027 AAI01028 BC101028 AAI01029 BC101029 AAI01030 BC101030 AAI01031 DB089501 XM_011542115 XP_011540417 XM_011542116 XP_011540418 XM_011542117 XP_011540419 XM_011542118 XP_011540420 XM_011542119 XP_011540421 XM_011542120 XP_011540422 XM_011542121 XP_011540423 XM_011542122 XP_011540424 XM_011542123 XP_011540425 XM_011542124 XP_011540426 XM_011542125 XP_011540427 XM_011546399 XP_011544701 XM_011546400 XP_011544702 XM_011546401 XP_011544703 XM_011546402 XP_011544704 XM_011546403 XP_011544705 XM_011546404 XP_011544706 XM_011546405 XP_011544707 XM_011546406 XP_011544708 XM_011546407 XP_011544709 XM_011546408 XP_011544710 XM_011546409 XP_011544711 XM_011546410 XP_011544712 XR_946752 XR_946753 XR_946754 XR_951571 XR_951572 XR_951573 NM_033467 NP_258428
Function Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity). {ECO:0000250}.
Subcellular Location Membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form produced by proteollytic cleavage also exists. {ECO:0000250}.
Tissue Specificity Predominantly expressed in testis. Weakly expressed in brain, kidney and heart. {ECO:0000269|PubMed:11560781}.

Neprilysin-2 (I-14) - sc-104450 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Neprilysin-like Protease beta antibody - ab81688 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Neprilysin-like Protease beta antibody (ab81688) at 1 µg/ml (in 5% skim milk / PBS buffer) + fetal liver lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Neprilysin-like Protease beta antibody - ab59447 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Neprilysin-like Protease beta antibody (ab59447) at 1/1000 dilutionLane 1 : Human prostate carcinoma 22Rv-1 lysate (treated with TNF-alpha) Lane 2 : Human prostate carcinoma 22Rv-1 lysate (treated with RA) Lane 3 : Human prostate carcinoma 22Rv-1 lysate (treated with Progesteron) Lysates/proteins at 10 µl per lane.

Anti-Neprilysin-like Protease beta antibody - ab59448 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Neprilysin-like Protease beta antibody (ab59448) at 1/1000 dilutionLane 1 : Human prostate carcinoma 22Rv-1 lysate (treated with TNF-alpha)Lane 2 : Human prostate carcinoma 22Rv-1 lysate (treated with RA) Lane 3 : Human prostate carcinoma 22Rv-1 lysated (treated with Progesteron) Lane 4 : Human prostate carcinoma 22Rv-1 lysate (treated with Testesteron) Lysates/proteins at 10 µl per lane.

Anti-Neprilysin-like Protease beta antibody - ab59449 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Neprilysin-like Protease beta antibody (ab59449) at 1/1000 dilutionLane 1 : Recombinant Human Neprilysin-2 at 0.04 µgLane 2 : Recombinant Human Neprilysin-2 at 0.02 µgLane 3 : Recombinant Human Neprilysin-2 at 0.01 µgLane 4 : Recombinant Human Neprilysin-2 at 0.005 µgLane 5 : Recombinant Human Neprilysin-1 at 0.04 µgLane 6 : Recombinant Human Neprilysin-1 at 0.02 µgLane 7 : Recombinant Human Neprilysin-1 at 0.01 µgLane 8 : Recombinant Human Neprilysin-1 at 0.005 µg

Anti-Neprilysin-like Protease beta antibody - ab59450 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Neprilysin-like Protease beta antibody (ab59450) at 1/1000 dilutionLane 1 : Recombinant Human Neprilysin-2 at 0.04 µgLane 2 : Recombinant Human Neprilysin-2 at 0.02 µgLane 3 : Recombinant Human Neprilysin-2 at 0.01 µgLane 4 : Recombinant Human Neprilysin-2 at 0.005 µgLane 5 : Recombinant Human Neprilysin-1 at 0.04 µgLane 6 : Recombinant Human Neprilysin-1 at 0.02 µgLane 7 : Recombinant Human Neprilysin-1 at 0.01 µgLane 8 : Recombinant Human Neprilysin-1 at 0.005 µg

Anti-Neprilysin-like Protease gamma antibody - ab186577 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-Neprilysin-like Protease gamma antibody - ab168182 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-Neprilysin-like Protease gamma antibody (ab168182) at 1/500 dilutionLane 1 : Neprilysin-like Protease gamma transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat anti-Mouse IgG HRP at 1/2500 dilution

Anti-MMEL1 Antibody (N-Terminus) - LS-C37505 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-MMEL1 Antibody (N-Terminus) - LS-C37506 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-MMEL1 Antibody (aa50-78, APC) - LS-C215821 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MMEL1 Antibody (aa50-78, Biotin) - LS-C215822 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MMEL1 Antibody (aa50-78, AP) - LS-C215820 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MMEL1 Antibody (aa50-78, FITC) - LS-C215823 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MMEL1 Antibody (aa50-78, PE) - LS-C215825 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MMEL1 Antibody (aa50-78, Azide-free, HRP) - LS-C215824 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MMEL1 Antibody (aa50-78) - LS-C323035 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MMEL1 Antibody (aa371-420) - LS-C81531 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal liver lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-MMEL1 Antibody (aa50-78) - LS-C157890 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
MMEL1 Antibody western blot of human Uterus tissue lysates (35 ug/lane). The MMEL1 antibody detected the MMEL1 protein (arrow).

Neprilysin-2/MMEL1 Antibody - AF2340 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal

Neprilysin-2/MMEL1 Antibody (353207) - MAB2340 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 353207

Neprilysin-2/MMEL1 Antibody - NBP1-59349 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MMELL1 Antibody [NBP1-59349] - Human Liver cell lysate, concentration 0.2-1 ug/ml.

Neprilysin-2/MMEL1 Antibody - NBP1-92126 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: MMELL1 Antibody [NBP1-92126] - Staining of human cell line U-251MG shows positivity in vesicles.

Neprilysin-2/MMEL1 Antibody - 32150002 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

SeP Antibody - NBP1-80766 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: SeP Antibody [NBP1-80766] - Staining of human prostate shows strong cytoplasmic positivity in glandular cells.
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