MMEL1

Gene Symbol MMEL1
Entrez Gene 79258
Alt Symbol MMEL2, NEP2, NEPII, NL1, NL2, SEP
Species Human
Gene Type protein-coding
Description membrane metallo-endopeptidase-like 1
Other Description NEP2(m)|membrane metallo-endopeptidase-like 2|neprilysin II|neprilysin-2|soluble secreted endopeptidase|zinc metallopeptidase
Swissprots Q495T6 B9DI79 Q5SZS6 Q96PH9 Q495T7 Q495T8
Accessions CAC09978 EAW56080 EAW56081 EAW56082 Q495T6 AF336981 AAL08942 AK093058 BAG52644 BC101027 AAI01028 BC101028 AAI01029 BC101029 AAI01030 BC101030 AAI01031 DB089501 XM_011542115 XP_011540417 XM_011542116 XP_011540418 XM_011542117 XP_011540419 XM_011542118 XP_011540420 XM_011542119 XP_011540421 XM_011542120 XP_011540422 XM_011542121 XP_011540423 XM_011542122 XP_011540424 XM_011542123 XP_011540425 XM_011542124 XP_011540426 XM_011542125 XP_011540427 XM_011546399 XP_011544701 XM_011546400 XP_011544702 XM_011546401 XP_011544703 XM_011546402 XP_011544704 XM_011546403 XP_011544705 XM_011546404 XP_011544706 XM_011546405 XP_011544707 XM_011546406 XP_011544708 XM_011546407 XP_011544709 XM_011546408 XP_011544710 XM_011546409 XP_011544711 XM_011546410 XP_011544712 XR_946752 XR_946753 XR_946754 XR_951571 XR_951572 XR_951573 NM_033467 NP_258428
Function Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity). {ECO:0000250}.
Subcellular Location Membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form produced by proteollytic cleavage also exists. {ECO:0000250}.
Tissue Specificity Predominantly expressed in testis. Weakly expressed in brain, kidney and heart. {ECO:0000269|PubMed:11560781}.

Neprilysin-2 CRISPR/Cas9 KO Plasmid (h) - sc-405449 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Neprilysin-2 HDR Plasmid (h) - sc-405449-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Neprilysin-2 Double Nickase Plasmid (h) - sc-405449-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Neprilysin-2 Double Nickase Plasmid (h2) - sc-405449-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Neprilysin-2 CRISPR Activation Plasmid (h) - sc-405449-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Neprilysin-2 CRISPR Activation Plasmid (h2) - sc-405449-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Neprilysin-2 Lentiviral Activation Particles (h) - sc-405449-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Neprilysin-2 Lentiviral Activation Particles (h2) - sc-405449-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Neprilysin-2 siRNA (h) - sc-88604 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Neprilysin-2 shRNA Plasmid (h) - sc-88604-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Neprilysin-2 shRNA (h) Lentiviral Particles - sc-88604-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN14422 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14422 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MMEL1 siRNA (Human) - CRJ2361 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MMEL1 (NM_033467.3) - SHH342820 from Creative biogene

Category siRNA
Species Reactivities Human

Human MMEL1 siRNA - orb272862 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MMEL1 shRNA Plasmid (Human) - CHJ2361 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MMEL1 miRNA 3'UTR clone - MiUTR3H-15507 from Creative biogene

Species Reactivities Human
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