SREBF2

Gene Symbol SREBF2
Entrez Gene 6721
Alt Symbol SREBP-2, SREBP2, bHLHd2
Species Human
Gene Type protein-coding
Description sterol regulatory element binding transcription factor 2
Other Description class D basic helix-loop-helix protein 2|sterol regulatory element-binding protein 2|sterol regulatory element-binding transcription factor 2
Swissprots Q12772 Q6GTH7 Q86V36 Q9UH04 Q05BD5
Accessions BAC57590 EAW60469 EAW60470 EAW60471 Q12772 AA035591 AK299914 BAG61752 AL834221 CAD38902 BC051385 AAH51385 BC051799 AAH51799 BC056158 AAH56158 CT841522 CAJ86452 CU013184 CAK54615 CU013472 CAK54914 U02031 AAA50746 XM_006724310 XP_006724373 XM_011530347 XP_011528649 NM_004599 NP_004590 NR_103834
Function Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. {ECO:0000250}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.
Tissue Specificity Ubiquitously expressed in adult and fetal tissues.

SREBP-2 (A-12) - sc-271616 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SREBP-2 (A-12): sc-271616. Western blot analysis of SREBP-2 expression in MOLT-4 whole cell lysate.

SREBP-2 (1C6) - sc-13552 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SREBP-2 (1C6): sc-13552. Western blot analysis of SREBP-2 expression in LNCaP (A) and PC-3 (B) whole cell lysates and KNRK nuclear extract (C).

SREBP-2 (C-6) - sc-271615 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SREBP-2 (C-6): sc-271615. Western blot analysis of SREBP-2 expression in LNCaP whole cell lysate.

SREBP-2 (H-164) - sc-5603 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SREBP-2 (H-164): sc-5603. Immunofluorescence staining of methanol-fixed U-937 cells showing cytoplasmic localization.

SREBP-2 (N-19) - sc-8151 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SREBP-2 (N-19): sc-8151. Western blot analysis of SREBP-2 expression in U-937 (A) and PC-3 (B) nuclear extracts.

Anti-SREBP2 antibody - N-terminal - ab189602 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SREBP2 antibody - N-terminal (ab189602) at 1/1000 dilutionLane 1 : Mouse brain total cell extractLane 2 : HeLa total cell extract

Anti-SREBF2 / SREBP2 Antibody (Internal) IHC-plus™ - LS-B12146 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-SREBF2 / SREBP2 Antibody (aa399-427, AP) - LS-C270343 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SREBF2 / SREBP2 Antibody (aa399-427, APC) - LS-C270344 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SREBF2 / SREBP2 Antibody (aa399-427, Biotin) - LS-C270345 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SREBF2 / SREBP2 Antibody (aa399-427, Azide-free, HRP) - LS-C270346 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SREBF2 / SREBP2 Antibody (aa399-427, FITC) - LS-C270347 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SREBF2 / SREBP2 Antibody (aa399-427, PE) - LS-C270349 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SREBF2 / SREBP2 Antibody (aa402-431) - LS-C325377 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SREBF2 / SREBP2 Antibody - LS-C109524 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate). A: Molt-4. 7.5% SDS PAGE. SREBF2 antibody diluted at 1:1000.

Anti-SREBF2 / SREBP2 Antibody (clone 1D2) - LS-C179708 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D2

Anti-SREBF2 / SREBP2 Antibody - LS-C334967 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using SREBF2 antibody.

Anti-SREBF2 / SREBP2 Antibody (aa117-380, clone 4G1) - LS-C339936 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4G1
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SREBF2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SREBF2.

Anti-SREBF2 / SREBP2 Antibody (aa434-483) IHC-plus™ - LS-B1002 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SREBP-2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1002 concentration 2.5 ug/ml.

Anti-SREBF2 / SREBP2 Antibody (aa300-350) - LS-C289825 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human SREBP2 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 ug) cells. Antibodies: Affinity purified rabbit anti-SREBP2 antibody used for WB at 0.4 ug/ml (A) and 1 ug/ml (B) and used for IP at 6 ug/mg lysate. SREBP2 was also immunoprecipitated by rabbit anti-SREBP2 antibody BL11235, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 30 seconds (B).

Anti-SREBF2 / SREBP2 Antibody (aa399-427) - LS-C161495 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SREBF2 antibody immunohistochemistry of formalin-fixed and paraffin-embedded human skin carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-SREBF2 / SREBP2 Antibody (aa441-473) - LS-C344698 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of lysates from Zebrafish and zebra fish muscle tissue lysate (from left to right) with (DANRE) srebf2 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35 ug per lane.

Anti-SREBF2 / SREBP2 Antibody (aa455-469) IHC-plus™ - LS-B1609 from LifeSpan Bioscience

Prices $395.00
Sizes 1 ea
Host Rabbit
Clonality Polyclonal
Anti-SREBP-2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1609 concentration 5 ug/ml.

Anti-SREBF2 / SREBP2 Antibody (aa304-353) IHC-plus™ - LS-B4695 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SREBP-2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4695 concentration 5 ug/ml.

SREBP2 Antibody - NB100-74543 from Novus Biologicals

Prices $129.00, $329.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: SREBP2 Antibody [NB100-74543] - Analysis of 25 ug of mouse liver (lane 1), rat liver (lane 2) and HepG2 (lane 3) cell lysates.
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