SREBF2

Gene Symbol SREBF2
Entrez Gene 6721
Alt Symbol SREBP-2, SREBP2, bHLHd2
Species Human
Gene Type protein-coding
Description sterol regulatory element binding transcription factor 2
Other Description class D basic helix-loop-helix protein 2|sterol regulatory element-binding protein 2|sterol regulatory element-binding transcription factor 2
Swissprots Q12772 Q6GTH7 Q86V36 Q9UH04 Q05BD5
Accessions BAC57590 EAW60469 EAW60470 EAW60471 Q12772 AA035591 AK299914 BAG61752 AL834221 CAD38902 BC051385 AAH51385 BC051799 AAH51799 BC056158 AAH56158 CT841522 CAJ86452 CU013184 CAK54615 CU013472 CAK54914 U02031 AAA50746 XM_006724310 XP_006724373 XM_011530347 XP_011528649 NM_004599 NP_004590 NR_103834
Function Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. {ECO:0000250}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.
Tissue Specificity Ubiquitously expressed in adult and fetal tissues.

SREBP-2 Transcription Factor Assay Kit - ab133111 from Abcam

Category Cellular Assay
Prices $494.00
Sizes 96 tests
Example of typical standard curve obtained using ab133111.

SREBP-2 Translocation Assay Kit (Cell-Based) - ab133114 from Abcam

Category Cellular Assay
Prices $376.00
Sizes 96 tests
Translocation of SREBP-2 into nuclei by U-18666A. Raw 264.7 cells were seeded in a 96-well plate at a density of 3 x 104 cells/well and cultured overnight. The next day, cells were treated with DMSO (vehicle) or 24 µM U-18666A for 72 hours. Panel A: Cells treated with DMSO alone demonstrate cytoplasmic localization of SREBP-2, indicating that most of cells have inactive protein. Panel B: U-18666A treatment for three days induced SREBP-2 translocation into the nuclei, indicating that blockage of cholesterol transport in these cells activates the protein.

Human SREBF2 / SREBP2 ELISA Kit (Sandwich ELISA) - LS-F12655 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 0.312
Range 0.312-20 ng/ml

SREBP2 Fluorometric Assay Kit - KA1378 from Novus Biologicals

Category Assay Kit
Prices $519.00
Sizes 1 kit

SREBP2 Colorimetric Assay Kit - KA1379 from Novus Biologicals

Category Assay Kit
Prices $659.00
Sizes 1 kit

Sterol regulatory element-binding protein 2, SREBF2, Human, ELISA Kit - E12196h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t
Range 0.312-20 ng/mL

SREBF2 Cell-Based Translocation Assay Kit - KA1378 from Acris Antibodies

Category ELISA Kit
Prices $470.00
Sizes 1 kit

SREBF2 Transcription Factor Assay Kit - KA1379 from Acris Antibodies

Category ELISA Kit
Prices $560.00
Sizes 1 kit

Sterol Regulatory Element Binding Proteins, ELISA Kit - MBS051995 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sterol Regulatory Element Binding Proteins, ELISA Kit - MBS014644 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sterol Regulatory Element Binding Proteins, ELISA Kit - MBS018231 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sterol Regulatory Element Binding Proteins, ELISA Kit - MBS080956 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sterol Regulatory Element Binding Proteins, ELISA Kit - MBS023363 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sterol Regulatory Element Binding Proteins, ELISA Kit - MBS080455 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sterol Regulatory Element Binding Proteins, ELISA Kit - MBS094535 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sterol Regulatory Element Binding Proteins, ELISA Kit - MBS091981 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sterol Regulatory Element Binding Proteins, ELISA Kit - MBS029523 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sterol Regulatory Element Binding Proteins, ELISA Kit - MBS022368 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.0ng/ml.
Range 6.25ng/ml-200ng/ml.

Sterol Regulatory Element Binding Proteins, ELISA Kit - MBS007791 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sterol Regulatory Element Binding Proteins, ELISA Kit - MBS038511 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sterol Regulatory Element Binding Proteins, ELISA Kit - MBS013430 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sterol Regulatory Element Binding Proteins, ELISA Kit - MBS040597 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sterol Regulatory Element Binding Proteins, ELISA Kit - MBS016282 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sterol Regulatory Element Binding Proteins, ELISA Kit - MBS037027 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sterol Regulatory Element Binding Proteins, ELISA Kit - MBS032700 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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