SREBF2

Gene Symbol SREBF2
Entrez Gene 6721
Alt Symbol SREBP-2, SREBP2, bHLHd2
Species Human
Gene Type protein-coding
Description sterol regulatory element binding transcription factor 2
Other Description class D basic helix-loop-helix protein 2|sterol regulatory element-binding protein 2|sterol regulatory element-binding transcription factor 2
Swissprots Q12772 Q6GTH7 Q86V36 Q9UH04 Q05BD5
Accessions BAC57590 EAW60469 EAW60470 EAW60471 Q12772 AA035591 AK299914 BAG61752 AL834221 CAD38902 BC051385 AAH51385 BC051799 AAH51799 BC056158 AAH56158 CT841522 CAJ86452 CU013184 CAK54615 CU013472 CAK54914 U02031 AAA50746 XM_006724310 XP_006724373 XM_011530347 XP_011528649 NM_004599 NP_004590 NR_103834
Function Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. {ECO:0000250}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.
Tissue Specificity Ubiquitously expressed in adult and fetal tissues.

SREBP-2 CRISPR/Cas9 KO Plasmid (h) - sc-400575 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SREBP-2 HDR Plasmid (h) - sc-400575-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SREBP-2 Double Nickase Plasmid (h) - sc-400575-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SREBP-2 Double Nickase Plasmid (h2) - sc-400575-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SREBP-2 CRISPR Activation Plasmid (h) - sc-400575-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SREBP-2 CRISPR Activation Plasmid (h2) - sc-400575-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SREBP-2 Lentiviral Activation Particles (h) - sc-400575-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SREBP-2 Lentiviral Activation Particles (h2) - sc-400575-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SREBP-2 siRNA (h) - sc-36559 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SREBP-2 shRNA Plasmid (h) - sc-36559-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SREBP-2 shRNA (h) Lentiviral Particles - sc-36559-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SREBP2 RNAi - H00006721-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU100781 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20564 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20564 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05875 from Sigma-Aldrich

Category miRNA

SREBF2 siRNA (Human) - CRH4589 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SREBF2 - MBS8219115 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SREBF2 (NM_004599.2) - SHH417740 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SREBF2(NM_004599.2) - SHL032398 from Creative biogene

Category siRNA
Species Reactivities Human

SREBF2 shRNA Plasmid (Human) - CHH4589 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SREBF2 miRNA 3'UTR clone - MiUTR1H-09899 from Creative biogene

Species Reactivities Human
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