| Gene Symbol |
SREBF2
|
| Entrez Gene |
6721
|
| Alt Symbol |
SREBP-2, SREBP2, bHLHd2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sterol regulatory element binding transcription factor 2
|
| Other Description |
class D basic helix-loop-helix protein 2|sterol regulatory element-binding protein 2|sterol regulatory element-binding transcription factor 2
|
| Swissprots |
Q12772 Q6GTH7 Q86V36 Q9UH04 Q05BD5
|
| Accessions |
BAC57590 EAW60469 EAW60470 EAW60471 Q12772 AA035591 AK299914 BAG61752 AL834221 CAD38902 BC051385 AAH51385 BC051799 AAH51799 BC056158 AAH56158 CT841522 CAJ86452 CU013184 CAK54615 CU013472 CAK54914 U02031 AAA50746 XM_006724310 XP_006724373 XM_011530347 XP_011528649 NM_004599 NP_004590 NR_103834
|
| Function |
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.
|
| Tissue Specificity |
Ubiquitously expressed in adult and fetal tissues.
|