| Gene Symbol |
TRPV2
|
| Entrez Gene |
51393
|
| Alt Symbol |
VRL, VRL-1, VRL1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily V, member 2
|
| Other Description |
OTRPC2|osm-9-like TRP channel 2|transient receptor potential cation channel subfamily V member 2|vanilloid receptor-like protein 1
|
| Swissprots |
A8K0Z0 Q9Y5S1 A6NML2 Q9Y670
|
| Accessions |
CAB70426 EAX04507 EAX04508 EAX04509 Q9Y5S1 AF103906 AAD41724 AF129112 AAD26363 AJ487963 CAD32310 AK001896 BAG50989 AK289705 BAF82394 BC018926 AAH18926 BC051305 AAH51305 DQ893607 ABM84533 DQ895145 ABM86071 XM_005256676 XP_005256733 XM_005256677 XP_005256734 XM_005256678 XP_005256735 XM_006721541 XP_006721604 XM_006721542 XP_006721605 XM_006721543 XP_006721606 XM_011523922 XP_011522224 XM_011523923 XP_011522225 XM_011523924 XP_011522226 XM_011523925 XP_011522227 NM_016113 NP_057197
|
| Function |
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. {ECO:0000269|PubMed:10201375}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250}.
|
| Top Pathways |
Inflammatory mediator regulation of TRP channels
|
![Western Blot: VRL1 Overexpression Lysate (Adult Normal) [NBL1-17341] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for VRL1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7749_VRL1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17341-img0002.jpg)