| Gene Symbol |
SMPD2
|
| Entrez Gene |
6610
|
| Alt Symbol |
ISC1, NSMASE, NSMASE1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
|
| Other Description |
N-SMase|lyso-PAF-PLC|lyso-platelet-activating factor-phospholipase C|neutral sphingomyelinase|sphingomyelin phosphodiesterase 2
|
| Swissprots |
O60906 Q9BWR3 Q5TED1
|
| Accessions |
EAW48346 O60906 AJ222801 CAA10995 AK310148 AK313515 BAG36295 BC000038 AAH00038 CA314251 DA672570 DQ891879 ABM82805 HQ447883 ADQ32367 XM_005267109 XP_005267166 XM_011536079 XP_011534381 XR_942566 NM_003080 NP_003071
|
| Function |
Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Top Pathways |
Sphingolipid signaling pathway, Sphingolipid metabolism
|
