SMPD2

Gene Symbol SMPD2
Entrez Gene 6610
Alt Symbol ISC1, NSMASE, NSMASE1
Species Human
Gene Type protein-coding
Description sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
Other Description N-SMase|lyso-PAF-PLC|lyso-platelet-activating factor-phospholipase C|neutral sphingomyelinase|sphingomyelin phosphodiesterase 2
Swissprots O60906 Q9BWR3 Q5TED1
Accessions EAW48346 O60906 AJ222801 CAA10995 AK310148 AK313515 BAG36295 BC000038 AAH00038 CA314251 DA672570 DQ891879 ABM82805 HQ447883 ADQ32367 XM_005267109 XP_005267166 XM_011536079 XP_011534381 XR_942566 NM_003080 NP_003071
Function Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF.
Subcellular Location Membrane; Multi-pass membrane protein.
Top Pathways Sphingolipid signaling pathway, Sphingolipid metabolism

nSMase1 Antibody - 3867 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using nSMase1 Antibody.

N-SMase (C-13) - sc-26212 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
N-SMase (C-13): sc-26212. Immunoperoxidase stain-ing of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic and membrane staining of myocytes.

N-SMase (H-300) - sc-366292 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

N-SMase (R-20) - sc-26215 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
N-SMase (R-20): sc-26215. Western blot analysis of N-SMase expression in non-transfected: sc-117752 (A) and mouse N-SMase transfected: sc-121909 (B) 293T whole cell lysates.

N-SMase (56-7) - sc-100593 from Santa Cruz Biotechnology

Prices $295.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
N-SMase (56-7): sc-100593. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lymph node tissue showing membrane localization.

Anti-nSMase antibody [EPR6718] - ab131330 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6718
All lanes : Anti-nSMase antibody [EPR6718] (ab131330) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : MOLT4 cell lysateLane 3 : K562 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-nSMase antibody - N-terminal - ab95061 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-nSMase antibody - N-terminal (ab95061) at 1/50 dilution (in TTBS/1% NFDM for 1 hr. at room temperature) + Mouse lung tissue lysate at 35 µgSecondaryEnzyme-linked secondary antibody (typically horseradish peroxidase or alkaline phosphatase) in TTBS/1% NFDM for 30 min. at room temperature.

Anti-SMPD2 Antibody (aa60-109) - LS-C40518 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
SMPD2 antibody LS-C40518 Western blot of HepG2 cell lysate.

Anti-SMPD2 Antibody (N-Terminus) - LS-C111029 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SMPD2 antibody LS-C111029 Western blot of COLO205 cell lysate.

Anti-SMPD2 Antibody (aa2-236, Biotin) - LS-C300447 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SMPD2 Antibody (aa2-236, FITC) - LS-C303836 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SMPD2 Antibody (aa1-424, Azide-free) - LS-C328792 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-SMPD2 Antibody - LS-C192420 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of SMPD2 pAb in extracts from mouse brain tissue.

Anti-SMPD2 Antibody (clone 2C9) - LS-C133441 from LifeSpan Bioscience

Prices $355.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2C9
Immunoperoxidase of monoclonal antibody to SMPD2 on formalin-fixed paraffin-embedded human lymph node. [antibody concentration 3 ug/ml]

Anti-SMPD2 Antibody - LS-C331311 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of brain tissue lysate using SMPD2 antibody.

Anti-SMPD2 Antibody (Internal, clone EPR6718) - LS-C154568 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6718
Immunofluorescent staining of U87-MG cells using anti-SMPD2 antibody.

Anti-SMPD2 Antibody (aa9-35) - LS-C161320 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of SMPD2 Antibody in mouse lung tissue lysates (35 ug/lane). SMPD2 (arrow) was detected using the purified antibody.

Anti-SMPD2 Antibody (aa2-236) - LS-C295609 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant SMPD2.

nSMase Antibody - NBP1-59937 from Novus Biologicals

Prices $139.00, $299.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

nSMase Antibody - NBP1-59936 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

nSMase Antibody (2C9) - H00006610-M01 from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2C9

nSMase Antibody - NBP1-87810 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

nSMase Antibody (4A10) - H00006610-M09 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4A10

Anti-SMPD2 antibody produced in rabbit - HPA018110 from Sigma-Aldrich

Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SMPD2: <B>Cat. No. HPA018110</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human prostate shows strong cytoplasmic and nuclear positivity in glandular cells.

Monoclonal Anti-SMPD2 antibody produced in mouse - SAB1404383 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4A10
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