ERCC6

Gene Symbol ERCC6
Entrez Gene 2074
Alt Symbol ARMD5, CKN2, COFS, COFS1, CSB, RAD26, UVSS1
Species Human
Gene Type protein-coding
Description excision repair cross-complementation group 6
Other Description ATP-dependent helicase ERCC6|Cockayne syndrome group B protein|DNA excision repair protein ERCC-6|cockayne syndrome protein CSB|excision repair cross-complementing rodent repair deficiency, complementation group 6
Swissprots D3DX94 Q5W0L9 Q03468
Accessions AAO13487 EAW93094 EAW93097 Q03468 AB209504 BAD92741 AK094670 AK130100 AK303022 BAG64148 BC127104 AAI27105 CR749388 CAH18238 DA457690 L04791 AAA52397 NM_000124 NP_000115
Function Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II- blocking lesions. {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16916636, ECO:0000269|PubMed:20541997}.
Subcellular Location Nucleus {ECO:0000269|PubMed:16128801}.
Top Pathways Nucleotide excision repair

CSB (B-10) - sc-137090 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CSB (B-10): sc-137090. Western blot analysis of CSB expression in HeLa (A) and BJAB (B) whole cell lysate.

CSB (E-6) - sc-398022 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CSB (E-6): sc-398022. Western blot analysis of CSB expression in HeLa (A) and BJAB (B) nuclear extracts.

CSB (H-300) - sc-25370 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CSB (H-300): sc-25370. Western blot analysis of CSB expression in untreated HeLa (A), UV-treated HeLa (B) and BJAB (C) nuclear extracts.

CSB (N-17) - sc-10458 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CSB (D-7) - sc-166042 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CSB (D-7): sc-166042. Western blot analysis of CSB expression in HeLa (A) and BJAB (B) nuclear extracts.

CSB (E-18) - sc-10459 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CSB (E-18): sc-10459. Western blot analysis of CSB expression in untreated HeLa (A), UV-treated HeLa (B) and BJAB (C) nuclear extracts.

Anti-CSB antibody - ab96089 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CSB antibody (ab96089) at 1/500 dilutionLane 1 : A431 whole cell lysateLane 2 : H1299 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-CSB antibody - ab118562 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab118562, at 5 µg/ml, staining CSB in formalin-fixed, paraffin-embedded Human Colon tissue by Immunohistochemistry.

Anti-CSB antibody - ab110850 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab110850 at 1/50 staining CSB in paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry; left panel shows staining without immunizing peptide right panel shows staining with immunizing peptide.

Anti-CSB antibody [553C5a] - ab66598 from Abcam

Prices $379.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 553C5a
Overlay histogram showing HeLa cells stained with ab66598 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab66598, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG2b [PLPV219] (ab91366, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-ERCC6 / CSB Antibody (aa242-261) - LS-C6714 from LifeSpan Bioscience

Prices $475.00
Sizes 150 µg
Host Mouse
Clonality Monoclonal

Anti-ERCC6 / CSB Antibody - LS-C65571 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-ERCC6 / CSB Antibody (clone 553C5a) - LS-C184622 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 553C5a

Anti-ERCC6 / CSB Antibody (aa1-50) - LS-C288153 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ERCC6 / CSB Antibody (aa1161-1211) - LS-C288156 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ERCC6 / CSB Antibody (aa1480-1493) IHC-plus™ - LS-B5098 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-ERCC6 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5098 concentration 3.75 ug/ml.

Anti-ERCC6 / CSB Antibody (aa800-850) - LS-C288154 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ERCC6 / CSB Antibody (aa346-766) IHC-plus™ - LS-B10773 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-CSB / ERCC6 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10773 concentration 7.5 ug/ml.

Anti-ERCC6 / CSB Antibody (aa717-731) - LS-C205013 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ERCC6 antibody (0.3 ug/ml) staining of HeLa nuclear lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-ERCC6 / CSB Antibody (aa141-190) - LS-C291261 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ERCC6 / CSB Antibody (aa784-833) - LS-C201334 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human HepG2. ERCC6 antibody dilution 1.0 ug/ml.

Anti-ERCC6L2 Antibody (aa12-43) - LS-C324501 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERCC6L2 Antibody (aa233-263) - LS-C324502 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERCC6 / CSB Antibody (clone 553C5a) - LS-C342654 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 553C5a
Western blot analysis of immunized recombinant protein, using anti-ERCC6 monoclonal antibody.

CSB Antibody - NB100-61070 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunoprecipitation: CSB Antibody [NB100-61070] - Detection of Human ERCC6 on HeLa whole cell lysate using NB100-61070. ERCC6 was also immunoprecipitated by another rabbit anti-ERCC6 antibody NB100-61068 and NB100-61069.
Search more