ERCC6

Gene Symbol ERCC6
Entrez Gene 2074
Alt Symbol ARMD5, CKN2, COFS, COFS1, CSB, RAD26, UVSS1
Species Human
Gene Type protein-coding
Description excision repair cross-complementation group 6
Other Description ATP-dependent helicase ERCC6|Cockayne syndrome group B protein|DNA excision repair protein ERCC-6|cockayne syndrome protein CSB|excision repair cross-complementing rodent repair deficiency, complementation group 6
Swissprots D3DX94 Q5W0L9 Q03468
Accessions AAO13487 EAW93094 EAW93097 Q03468 AB209504 BAD92741 AK094670 AK130100 AK303022 BAG64148 BC127104 AAI27105 CR749388 CAH18238 DA457690 L04791 AAA52397 NM_000124 NP_000115
Function Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II- blocking lesions. {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16916636, ECO:0000269|PubMed:20541997}.
Subcellular Location Nucleus {ECO:0000269|PubMed:16128801}.
Top Pathways Nucleotide excision repair

excision repair cross-complementing rodent repair deficiency, complementation group 6, ELISA Kit - MBS9328001 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human ERCC6 ELISA Kit - E013801 from Biobool

Category ELISA Kit
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