ERCC6

Gene Symbol ERCC6
Entrez Gene 2074
Alt Symbol ARMD5, CKN2, COFS, COFS1, CSB, RAD26, UVSS1
Species Human
Gene Type protein-coding
Description excision repair cross-complementation group 6
Other Description ATP-dependent helicase ERCC6|Cockayne syndrome group B protein|DNA excision repair protein ERCC-6|cockayne syndrome protein CSB|excision repair cross-complementing rodent repair deficiency, complementation group 6
Swissprots D3DX94 Q5W0L9 Q03468
Accessions AAO13487 EAW93094 EAW93097 Q03468 AB209504 BAD92741 AK094670 AK130100 AK303022 BAG64148 BC127104 AAI27105 CR749388 CAH18238 DA457690 L04791 AAA52397 NM_000124 NP_000115
Function Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II- blocking lesions. {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16916636, ECO:0000269|PubMed:20541997}.
Subcellular Location Nucleus {ECO:0000269|PubMed:16128801}.
Top Pathways Nucleotide excision repair

CSB CRISPR/Cas9 KO Plasmid (h) - sc-401287 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSB HDR Plasmid (h) - sc-401287-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSB Double Nickase Plasmid (h) - sc-401287-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSB Double Nickase Plasmid (h2) - sc-401287-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSB CRISPR Activation Plasmid (h) - sc-401287-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSB CRISPR Activation Plasmid (h2) - sc-401287-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSB Lentiviral Activation Particles (h) - sc-401287-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSB Lentiviral Activation Particles (h2) - sc-401287-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSB siRNA (h) - sc-37794 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CSB shRNA Plasmid (h) - sc-37794-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CSB shRNA (h) Lentiviral Particles - sc-37794-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CSB RNAi - H00002074-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU101511 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU220581 from Sigma-Aldrich

Category siRNA
Prices $140.00, $140.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7953 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7953 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11924 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11924

ERCC6 siRNA (Human) - CRH1449 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ERCC6 - MBS8206560 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ERCC6 (NM_000124.2) - SHH286937 from Creative biogene

Category siRNA
Species Reactivities Human

ERCC6 shRNA Plasmid (Human) - CHH1449 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ERCC6 miRNA 3'UTR clone - MiUTR4H-TG03143 from Creative biogene

Species Reactivities Human
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