| Gene Symbol |
ERCC6
|
| Entrez Gene |
2074
|
| Alt Symbol |
ARMD5, CKN2, COFS, COFS1, CSB, RAD26, UVSS1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
excision repair cross-complementation group 6
|
| Other Description |
ATP-dependent helicase ERCC6|Cockayne syndrome group B protein|DNA excision repair protein ERCC-6|cockayne syndrome protein CSB|excision repair cross-complementing rodent repair deficiency, complementation group 6
|
| Swissprots |
D3DX94 Q5W0L9 Q03468
|
| Accessions |
AAO13487 EAW93094 EAW93097 Q03468 AB209504 BAD92741 AK094670 AK130100 AK303022 BAG64148 BC127104 AAI27105 CR749388 CAH18238 DA457690 L04791 AAA52397 NM_000124 NP_000115
|
| Function |
Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II- blocking lesions. {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16916636, ECO:0000269|PubMed:20541997}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16128801}.
|
| Top Pathways |
Nucleotide excision repair
|