ERCC6

Gene Symbol	ERCC6
Entrez Gene	2074
Alt Symbol	ARMD5, CKN2, COFS, COFS1, CSB, RAD26, UVSS1
Species	Human
Gene Type	protein-coding
Description	excision repair cross-complementation group 6
Other Description	ATP-dependent helicase ERCC6|Cockayne syndrome group B protein|DNA excision repair protein ERCC-6|cockayne syndrome protein CSB|excision repair cross-complementing rodent repair deficiency, complementation group 6
Swissprots	D3DX94 Q5W0L9 Q03468
Accessions	AAO13487 EAW93094 EAW93097 Q03468 AB209504 BAD92741 AK094670 AK130100 AK303022 BAG64148 BC127104 AAI27105 CR749388 CAH18238 DA457690 L04791 AAA52397 NM_000124 NP_000115
Function	Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II- blocking lesions. {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16916636, ECO:0000269|PubMed:20541997}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:16128801}.
Top Pathways	Nucleotide excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CSB peptide - ab27761 from Abcam Category Peptide

Human CSB protein fragment - ab114506 from Abcam Category Protein Source Wheat germ Species Human

ERCC6 / CSB Blocking Peptide - LS-E25501 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CSB Protein - H00002074-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ERCC6 - H00002074-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ERCC6 - H00002074-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ERCC6 fusion protein - ag18009 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

ERCC6 fusion protein - ag18260 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human ERCC6, His-tagged - ERCC6-2672H from Creative Biomart Category Protein Source E. coli .

Recombinant Human ERCC6 - ERCC6-26417TH from Creative Biomart Category Protein Source Wheat germ

ERCC6 Blocking Peptide - CBP3927 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Recombinant Human DNA excision repair protein ERCC-6(ERCC6) ,partial - CSB-YP007774HU CSB-EP007774HU CSB-BP007774HU CSB-MP007774HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ERCC6 - TP319020 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

ERCC6, Peptide - MBS428522 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig, Bovine

ERCC6 Blocking Peptide - abx162420 from Abbexa Category Peptide Species Human, Mouse, Rat

ERCC6 Peptide, Human - M34GP05038H from Creative Peptides Category Peptide Source Synthetic. Species Human

ERCC6 peptide - orb256814 from Biorbyt Category Peptide Prices $272.00, $519.00 Sizes 1 mg, 5 mg

DNA excision repair protein ERCC-6 (ERCC6), partial, Recombinant Protein - MBS966143 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ERCC6, Recombinant Protein - MBS638088 from MyBioSource Category Protein Prices $615.00 Sizes 2 µg Source Human, Recombinant

Excision Repair Cross Complementing Rodent Repair Deficiency Complementation 6 (ERCC6), Recombinant Protein - MBS2086855 from MyBioSource Category Protein Prices $160.00, $320.00, $495.00 Sizes 10 µg, 50 µg, 100 µg Source E Coli Species Human

CSB Recombinant Protein Antigen - NBP2-57574PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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