Gene Symbol | SIVA1 |
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Entrez Gene | 10572 |
Alt Symbol | CD27BP, SIVA, Siva-1, Siva-2 |
Species | Human |
Gene Type | protein-coding |
Description | SIVA1, apoptosis-inducing factor |
Other Description | CD27-binding (Siva) protein|apoptosis regulatory protein Siva |
Swissprots | Q96P98 O15304 Q9UPD6 |
Accessions | DAA01049 EAW81877 EAW81878 EAW81879 EAW81880 O15304 AF033111 AAD50057 AF401214 AAL02171 AK124078 AK128704 AK223332 BAD97052 AK300415 BAG62144 AK316457 BAH14828 AK316550 BAG65628 BC034562 AAH34562 BU195069 CK001877 HQ447960 ADQ32443 XM_011536360 XP_011534662 NM_006427 NP_006418 NM_021709 NP_068355 |
Function | Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa- B and promotes T-cell receptor-mediated apoptosis. {ECO:0000269|PubMed:12011449, ECO:0000269|PubMed:14739602, ECO:0000269|PubMed:15034012, ECO:0000269|PubMed:15958577, ECO:0000269|PubMed:16491128}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15034012}. Nucleus {ECO:0000269|PubMed:15034012}. Note=In the nucleus, accumulates in dot-like structures. |
Tissue Specificity | Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon. |
Human SIVA full length protein - ab161050 from Abcam
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Human SIVA full length protein - ab171470 from Abcam
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SIVA1 / SIVA Antibody Blocking Peptide - LS-E31207 from LifeSpan Bioscience
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SIVA Recombinant Protein - H00010572-P01 from Novus Biologicals
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Recombinant Human SIVA Protein - NBP2-22808 from Novus Biologicals
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Human SIVA1 protein - orb244543 from Biorbyt
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Human SIVA1 protein - orb245991 from Biorbyt
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SIVA1 protein (His tag) - 80R-3493 from Fitzgerald
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SIVA1 / SIVA (1-175, His-tag) - AR51184PU-N from Acris Antibodies
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SIVA1 / SIVA (1-175, His-tag) - AR51184PU-S from Acris Antibodies
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SIVA1 / SIVA - H00010572-P01-10 from Acris Antibodies
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SIVA1 / SIVA - H00010572-P01-25 from Acris Antibodies
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SIVA1 / SIVA (N-term) Control Peptide - AP55603CP-N from Acris Antibodies
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SIVA1, 1-175aa, Human, His tag, E.coli - 01-P2360 from ARP American Research Products
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SIVA Peptide - 6621P from ProSci
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SIVA1 fusion protein - ag3654 from Proteintech Group
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Recombinant Human SIVA1, apoptosis-inducing factor, His-tagged - SIVA1-277H from Creative Biomart
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Recombinant Human SIVA1, His-tagged - SIVA1-3584H from Creative Biomart
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Recombinant CD27 Binding Protein (CD27BP) - RPM233Hu01 from Uscn Life Science Inc.
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Recombinant CD27 Binding Protein (CD27BP) - RPM233Hu01 from Cloud-clone
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Recombinant Human Apoptosis regulatory protein Siva(SIVA1) - CSB-YP021347HU CSB-BP021347HU CSB-MP021347HU from Cusabio
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Recombinant Human Apoptosis regulatory protein Siva(SIVA1) - CSB-EP021347HU from Cusabio
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SIVA1, 1-175aa, Human, His tag, E.coli (Denatured) - ATGP2360 from ATGen
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SIVA1 Protein - abx163739 from Abbexa
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SIVA1 / SIVA (transcript variant 1) - TP315680 from Acris Antibodies
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