| Gene Symbol |
AZU1
|
| Entrez Gene |
566
|
| Alt Symbol |
AZAMP, AZU, CAP37, HBP, HUMAZUR, NAZC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
azurocidin 1
|
| Other Description |
azurocidin|cationic antimicrobial protein 37|cationic antimicrobial protein CAP37|heparin-binding protein|neutrophil azurocidin
|
| Swissprots |
Q9UCM1 Q52LG4 P80014 P20160 Q9UCT5
|
| Accessions |
AAB59353 EAW69592 P20160 BC044940 AAH44940 BC069495 AAH69495 BC093931 AAH93931 BC093933 AAH93933 HQ448471 ADQ32951 X58794 CAA41601 NM_001700 NP_001691
|
| Function |
This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram- negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity aga
|
| Subcellular Location |
Cytoplasmic granule. Note=Cytoplasmic granules of neutrophils.
|
![Western Blot: Azurocidin/CAP37/HBP Overexpression Lysate (Denatured) [H00000566-T01] - Lane 1: AZU1 transfected lysate (26.9 KDa) Lane 2: Non-transfected lysate.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/28090_Azurocidin-CAP37-HBP-Overexpression-Lysate-(Denatured)-Western-Blot-H00000566-T01-img0002.jpg)