AZU1
| Gene Symbol | AZU1 |
|---|---|
| Entrez Gene | 566 |
| Alt Symbol | AZAMP, AZU, CAP37, HBP, HUMAZUR, NAZC |
| Species | Human |
| Gene Type | protein-coding |
| Description | azurocidin 1 |
| Other Description | azurocidin|cationic antimicrobial protein 37|cationic antimicrobial protein CAP37|heparin-binding protein|neutrophil azurocidin |
| Swissprots | Q9UCM1 Q52LG4 P80014 P20160 Q9UCT5 |
| Accessions | AAB59353 EAW69592 P20160 BC044940 AAH44940 BC069495 AAH69495 BC093931 AAH93931 BC093933 AAH93933 HQ448471 ADQ32951 X58794 CAA41601 NM_001700 NP_001691 |
| Function | This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram- negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity aga |
| Subcellular Location | Cytoplasmic granule. Note=Cytoplasmic granules of neutrophils. |
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