Gene Symbol | AZU1 |
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Entrez Gene | 566 |
Alt Symbol | AZAMP, AZU, CAP37, HBP, HUMAZUR, NAZC |
Species | Human |
Gene Type | protein-coding |
Description | azurocidin 1 |
Other Description | azurocidin|cationic antimicrobial protein 37|cationic antimicrobial protein CAP37|heparin-binding protein|neutrophil azurocidin |
Swissprots | Q9UCM1 Q52LG4 P80014 P20160 Q9UCT5 |
Accessions | AAB59353 EAW69592 P20160 BC044940 AAH44940 BC069495 AAH69495 BC093931 AAH93931 BC093933 AAH93933 HQ448471 ADQ32951 X58794 CAA41601 NM_001700 NP_001691 |
Function | This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram- negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity aga |
Subcellular Location | Cytoplasmic granule. Note=Cytoplasmic granules of neutrophils. |
azurocidin CRISPR/Cas9 KO Plasmid (h) - sc-407698 from Santa Cruz Biotechnology
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azurocidin HDR Plasmid (h) - sc-407698-HDR from Santa Cruz Biotechnology
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azurocidin Double Nickase Plasmid (h) - sc-407698-NIC from Santa Cruz Biotechnology
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azurocidin Double Nickase Plasmid (h2) - sc-407698-NIC-2 from Santa Cruz Biotechnology
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azurocidin CRISPR Activation Plasmid (h) - sc-407698-ACT from Santa Cruz Biotechnology
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azurocidin CRISPR Activation Plasmid (h2) - sc-407698-ACT-2 from Santa Cruz Biotechnology
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azurocidin Lentiviral Activation Particles (h) - sc-407698-LAC from Santa Cruz Biotechnology
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azurocidin Lentiviral Activation Particles (h2) - sc-407698-LAC-2 from Santa Cruz Biotechnology
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azurocidin siRNA (h) - sc-42966 from Santa Cruz Biotechnology
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azurocidin shRNA Plasmid (h) - sc-42966-SH from Santa Cruz Biotechnology
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azurocidin shRNA (h) Lentiviral Particles - sc-42966-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU125001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3792 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3792 from Sigma-Aldrich
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AZU1 siRNA (Human) - CRH0386 from Cohesion Biosciences
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AZU1 - MBS8236604 from MyBioSource
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shRNA set against Human AZU1 (NM_001700.3) - SHH244050 from Creative biogene
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Human AZU1 siRNA - orb260888 from Biorbyt
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AZU1 shRNA Plasmid (Human) - CHH0386 from Cohesion Biosciences
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AZU1 miRNA 3'UTR clone - MiUTR1H-00759 from Creative biogene
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