TLE1

Gene Symbol TLE1
Entrez Gene 7088
Alt Symbol ESG, ESG1, GRG1
Species Human
Gene Type protein-coding
Description transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
Other Description enhancer of split groucho-like protein 1|transducin-like enhancer protein 1
Swissprots Q969V9 Q5T3G4 A8K495 Q04724
Accessions EAW62636 EAW62637 Q04724 AB209854 BAD93091 AK290860 BAF83549 AK293606 BAG57070 AK304565 BAG65357 AY129016 AAM98759 BC000228 BC010100 AAH10100 BC015747 AAH15747 DB211613 DQ893273 ABM84199 DQ896604 ABM87603 EU831620 ACE87220 EU831706 ACE86540 M99435 AAA61192 XM_005252151 XP_005252208 XM_005252152 XP_005252209 XM_005252153 XP_005252210 XM_005252154 XP_005252211 XM_005252156 XP_005252213 XM_005252162 XP_005252219 XM_005252163 XP_005252220 XM_006717258 XP_006717321 XM_006717259 XP_006717322 XM_006717260 XP_006717323 XM_006717261 XP_006717324 XM_006717262 XP_006717325 XM_006717263 XP_006717326 XM_011518951 XP_011517253 NM_001303103 NP_001290032 NM_001303104 NP_001290033 NM_005077 NP_005068
Function Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. {ECO:0000269|PubMed:10660609}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12397081}. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
Tissue Specificity In all tissues examined, mostly in brain, liver and muscle.

TLE1/2/3/4 Antibody - 4681 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of cell extracts from various cell types using TLE1/2/3/4 Antibody.

TLE (C-19) - sc-13373 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TLE (C-19): sc-13373. Western blot analysis of TLE expression in Jurkat nuclear extract (A) and F9 whole cell lysate (B).

TLE1 (F-4) - sc-137098 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TLE1 (F-4): sc-137098. Western blot analysis of TLE1 expression in non-transfected: sc-117752 (A) and human TLE1 transfected: sc-171466 (B) 293T whole cell lysates.

TLE1 (C-7) - sc-137097 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TLE1 (C-7): sc-137097. Western blot analysis of TLE1 expression in non-transfected: sc-117752 (A) and human TLE1 transfected: sc-171466 (B) 293T whole cell lysates.

TLE1 (M-101) - sc-9121 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TLE1 (M-101): sc-9121. Western blot analysis of TLE1 expression in 293T whole cell lysate.

TLE1 (N-18) - sc-13368 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TLE1 (N-18): sc-13368. Western blot analysis of TLE1 expression in non-transfected: sc-117752 (A) and human TLE1 transfected: sc-171466 (B) 293T whole cell lysates.

Anti-TLE 1 antibody - ab155046 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TLE 1 antibody (ab155046) at 1/1000 dilution + 293T whole cell lysate at 30 µg

Anti-TLE 1 antibody - ab89782 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-TLE 1 antibody (ab89782) at 1 µg/ml + human liver tissue lysate at 50 µg

Anti-TLE 1 antibody - ab192660 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TLE 1 antibody - ab125183 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TLE 1 antibody (ab125183) at 0.1 µg/mlLane 1 : 293T whole cell lysate at 50 µgLane 2 : 293T whole cell lysate at 15 µgLane 3 : Jurkat whole cell lysate at 50 µgLane 4 : HeLa whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-TLE 1 antibody [1F5] - ab131648 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F5
All lanes : Anti-TLE 1 antibody [1F5] (ab131648) at 1/2000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cells transfected with pCMV6-ENTRY TLE1 cDNALysates/proteins at 5 µg per lane.

Anti-TLE 1 antibody [EPR9386(2)] - ab183742 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9386(2)
All lanes : Anti-TLE 1 antibody [EPR9386(2)] (ab183742) at 1/1000 dilutionLane 1 : SH-SY5Y cell lysateLane 2 : HepG2 cell lysateLane 3 : Jurkat cell lysateLane 4 : HeLa cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-TLE 1 antibody [EPR9386(2)] (Alexa Fluor® 488) - ab198523 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9386(2)
ab198523 staining TLE 1 in HepG2 cells. The cells were fixed with 100% methanol (5 min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab198523 at 1/100 dilution (shown in green) and ab195889, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 594), at 1/250 dilution (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).This product also gave a positive signal under the same testing conditions in HepG2 cells fixed with 4% formaldehyde (10 min).

Anti-TLE 1 antibody [EPR9386(2)] (Alexa Fluor® 647) - ab198525 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9386(2)
ab198525 staining TLE 1 in HepG2 cells. The cells were fixed with 4% formaldehyde (10 min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab198525 at 1/100 dilution (shown in red) and ab195887, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 488), at 1/250 dilution (shown in green). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).This product also gave a positive signal under the same testing conditions in HepG2 cells fixed with 100% methanol (5min).

Anti-TLE1 / TLE 1 Antibody (aa11-200) - LS-C132611 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-TLE1 / TLE 1 Antibody (aa181-198) - LS-C7308 from LifeSpan Bioscience

Prices $355.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TLE1 / TLE 1 Antibody (aa215-264) - LS-C109656 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TLE1 antibody LS-C109656 Western blot of PANC1 cell lysate.

Anti-TLE1 / TLE 1 Antibody (aa199-228) - LS-C161906 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of TLE1 Antibody in Jurkat cell line lysates (35 ug/lane). TLE1 (arrow) was detected using the purified antibody.

Anti-TLE1 / TLE 1 Antibody (Internal, clone 381CT18.5.1, APC) - LS-C250450 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 381CT18.5.1

Anti-TLE1 / TLE 1 Antibody (aa199-228) - LS-C161907 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Mouse
Clonality Monoclonal
TLE1 Antibody western blot of A549 cell line lysates (35 ug/lane). The TLE1 antibody detected the TLE1 protein (arrow).

Anti-TLE1 / TLE 1 Antibody (aa199-228) - LS-C161908 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
TLE1 antibody western blot of A549 cell line lysates (35 ug/lane). The TLE1 antibody detected the TLE1 protein (arrow).

Anti-TLE1 / TLE 1 Antibody (Internal, clone 381CT18.5.1, AP) - LS-C250451 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 381CT18.5.1

Anti-TLE1 / TLE 1 Antibody (Internal, clone 381CT18.5.1, FITC) - LS-C250453 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 381CT18.5.1

Anti-TLE1 / TLE 1 Antibody (Internal, clone 381CT18.5.1, Biotin) - LS-C250452 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 381CT18.5.1

Anti-TLE1 / TLE 1 Antibody (Internal, clone 381CT18.5.1, Azide-free, HRP) - LS-C250454 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 381CT18.5.1
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