| Gene Symbol |
TLE1
|
| Entrez Gene |
7088
|
| Alt Symbol |
ESG, ESG1, GRG1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
|
| Other Description |
enhancer of split groucho-like protein 1|transducin-like enhancer protein 1
|
| Swissprots |
Q969V9 Q5T3G4 A8K495 Q04724
|
| Accessions |
EAW62636 EAW62637 Q04724 AB209854 BAD93091 AK290860 BAF83549 AK293606 BAG57070 AK304565 BAG65357 AY129016 AAM98759 BC000228 BC010100 AAH10100 BC015747 AAH15747 DB211613 DQ893273 ABM84199 DQ896604 ABM87603 EU831620 ACE87220 EU831706 ACE86540 M99435 AAA61192 XM_005252151 XP_005252208 XM_005252152 XP_005252209 XM_005252153 XP_005252210 XM_005252154 XP_005252211 XM_005252156 XP_005252213 XM_005252162 XP_005252219 XM_005252163 XP_005252220 XM_006717258 XP_006717321 XM_006717259 XP_006717322 XM_006717260 XP_006717323 XM_006717261 XP_006717324 XM_006717262 XP_006717325 XM_006717263 XP_006717326 XM_011518951 XP_011517253 NM_001303103 NP_001290032 NM_001303104 NP_001290033 NM_005077 NP_005068
|
| Function |
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. {ECO:0000269|PubMed:10660609}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12397081}. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
|
| Tissue Specificity |
In all tissues examined, mostly in brain, liver and muscle.
|