TLE1

Gene Symbol	TLE1
Entrez Gene	7088
Alt Symbol	ESG, ESG1, GRG1
Species	Human
Gene Type	protein-coding
Description	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
Other Description	enhancer of split groucho-like protein 1|transducin-like enhancer protein 1
Swissprots	Q969V9 Q5T3G4 A8K495 Q04724
Accessions	EAW62636 EAW62637 Q04724 AB209854 BAD93091 AK290860 BAF83549 AK293606 BAG57070 AK304565 BAG65357 AY129016 AAM98759 BC000228 BC010100 AAH10100 BC015747 AAH15747 DB211613 DQ893273 ABM84199 DQ896604 ABM87603 EU831620 ACE87220 EU831706 ACE86540 M99435 AAA61192 XM_005252151 XP_005252208 XM_005252152 XP_005252209 XM_005252153 XP_005252210 XM_005252154 XP_005252211 XM_005252156 XP_005252213 XM_005252162 XP_005252219 XM_005252163 XP_005252220 XM_006717258 XP_006717321 XM_006717259 XP_006717322 XM_006717260 XP_006717323 XM_006717261 XP_006717324 XM_006717262 XP_006717325 XM_006717263 XP_006717326 XM_011518951 XP_011517253 NM_001303103 NP_001290032 NM_001303104 NP_001290033 NM_005077 NP_005068
Function	Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. {ECO:0000269|PubMed:10660609}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12397081}. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
Tissue Specificity	In all tissues examined, mostly in brain, liver and muscle.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TLE 1 full length protein - ab132156 from Abcam Category Protein Source Wheat germ Species Human

TLE1 / TLE 1 Antibody Blocking Peptide - LS-E11322 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TLE1 / TLE 1 Antibody Blocking Peptide - LS-E10221 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TLE1 Protein - H00007088-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TLE1-Antibody-Center-Blocking-Peptide - BP9614c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TLE1 Blocking Peptide - 33R-8077 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TLE1 - H00007088-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

TLE1 - H00007088-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

TLE1 fusion protein - ag1801 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

TLE1 fusion protein - Ag17452 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

TLE1 fusion protein - ag21327 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

TLE1 fusion protein - ag17299 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

TLE1 - TP304037 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

TLE1-Blocking-Peptide-N-term - BP21035a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TLE1-Blocking-Peptide-N-term - BP21016a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TLE1 Peptide, Human - M34GP15988H from Creative Peptides Category Peptide Source Synthetic. Species Human

TLE1/2/3/4 Blocking Peptide - CBP7458 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Zebrafish

TLE1 Recombinant Protein Antigen - NBP2-56388PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Recombinant Human TLE1 Protein, MYC/DDK-tagged - TLE1-22H from Creative Biomart Category Protein Source HEK293T Species Human

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