TLE1

Gene Symbol	TLE1
Entrez Gene	7088
Alt Symbol	ESG, ESG1, GRG1
Species	Human
Gene Type	protein-coding
Description	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
Other Description	enhancer of split groucho-like protein 1|transducin-like enhancer protein 1
Swissprots	Q969V9 Q5T3G4 A8K495 Q04724
Accessions	EAW62636 EAW62637 Q04724 AB209854 BAD93091 AK290860 BAF83549 AK293606 BAG57070 AK304565 BAG65357 AY129016 AAM98759 BC000228 BC010100 AAH10100 BC015747 AAH15747 DB211613 DQ893273 ABM84199 DQ896604 ABM87603 EU831620 ACE87220 EU831706 ACE86540 M99435 AAA61192 XM_005252151 XP_005252208 XM_005252152 XP_005252209 XM_005252153 XP_005252210 XM_005252154 XP_005252211 XM_005252156 XP_005252213 XM_005252162 XP_005252219 XM_005252163 XP_005252220 XM_006717258 XP_006717321 XM_006717259 XP_006717322 XM_006717260 XP_006717323 XM_006717261 XP_006717324 XM_006717262 XP_006717325 XM_006717263 XP_006717326 XM_011518951 XP_011517253 NM_001303103 NP_001290032 NM_001303104 NP_001290033 NM_005077 NP_005068
Function	Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. {ECO:0000269|PubMed:10660609}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12397081}. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
Tissue Specificity	In all tissues examined, mostly in brain, liver and muscle.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TLE1 - H00007088-T01 from Acris Antibodies Prices $320.00 Sizes 100 µl

TLE1 293 Cell Lysate - 408215 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Drosophila

TLE1 Overexpression Lysate (Denatured) - H00007088-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

TLE1 Overexpression Lysate (Native) - NBL1-16944 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

TLE1 (h): 293T Lysate - sc-171466 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

TLE1 (h3): 293T Lysate - sc-178061 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

TLE1 Over-expression Lysate Product - GWB-3B9E55 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

TLE1 Overexpression Lysate (Denatured) - H00007088-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human TLE1 Knockdown Stable Cell Line - CSC-DC015988 from Creative biogene Category Cell Line Species Human

Human TLE1 Knockout Cell Line-HeLa - CSC-RT0538 from Creative biogene Category Cell Line Species Human

Human TLE1 Knockout Cell Line-HEK293T - CSC-RT1673 from Creative biogene Category Cell Line Species Human

TLE1 KO Cell Lysate-HeLa - CLKO-0043 from Creative biogene Category Cell Lysate

TLE1 KO Cell Lysate-HEK293T - CLKO-1520 from Creative biogene Category Cell Lysate

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