TLE1

Gene Symbol TLE1
Entrez Gene 7088
Alt Symbol ESG, ESG1, GRG1
Species Human
Gene Type protein-coding
Description transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
Other Description enhancer of split groucho-like protein 1|transducin-like enhancer protein 1
Swissprots Q969V9 Q5T3G4 A8K495 Q04724
Accessions EAW62636 EAW62637 Q04724 AB209854 BAD93091 AK290860 BAF83549 AK293606 BAG57070 AK304565 BAG65357 AY129016 AAM98759 BC000228 BC010100 AAH10100 BC015747 AAH15747 DB211613 DQ893273 ABM84199 DQ896604 ABM87603 EU831620 ACE87220 EU831706 ACE86540 M99435 AAA61192 XM_005252151 XP_005252208 XM_005252152 XP_005252209 XM_005252153 XP_005252210 XM_005252154 XP_005252211 XM_005252156 XP_005252213 XM_005252162 XP_005252219 XM_005252163 XP_005252220 XM_006717258 XP_006717321 XM_006717259 XP_006717322 XM_006717260 XP_006717323 XM_006717261 XP_006717324 XM_006717262 XP_006717325 XM_006717263 XP_006717326 XM_011518951 XP_011517253 NM_001303103 NP_001290032 NM_001303104 NP_001290033 NM_005077 NP_005068
Function Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. {ECO:0000269|PubMed:10660609}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12397081}. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
Tissue Specificity In all tissues examined, mostly in brain, liver and muscle.

TLE1 CRISPR/Cas9 KO Plasmid (h) - sc-400343 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLE1 HDR Plasmid (h) - sc-400343-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLE1 Double Nickase Plasmid (h) - sc-400343-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLE1 Double Nickase Plasmid (h2) - sc-400343-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLE1 CRISPR Activation Plasmid (h) - sc-400343-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLE1 CRISPR Activation Plasmid (h2) - sc-400343-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLE1 Lentiviral Activation Particles (h) - sc-400343-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLE1 Lentiviral Activation Particles (h2) - sc-400343-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TLE1 siRNA (h) - sc-38558 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TLE1 shRNA Plasmid (h) - sc-38558-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TLE1 shRNA (h) Lentiviral Particles - sc-38558-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU083211 from Sigma-Aldrich

Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN21389 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21389 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05028 from Sigma-Aldrich

Category miRNA

TLE1 siRNA (Human) - CRH4855 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TLE1 - MBS8235079 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TLE1(NM_005077.3) - SHG210493 from Creative biogene

Category siRNA
Species Reactivities Human

Human TLE1 siRNA - orb265357 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TLE1 shRNA Plasmid (Human) - CHH4855 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TLE1 miRNA 3'UTR clone - MiUTR1H-10427 from Creative biogene

Species Reactivities Human
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