COPS3

Gene Symbol	COPS3
Entrez Gene	8533
Alt Symbol	CSN3, SGN3
Species	Human
Gene Type	protein-coding
Description	COP9 signalosome subunit 3
Other Description	COP9 complex subunit 3|COP9 constitutive photomorphogenic homolog subunit 3|COP9 signalosome complex subunit 3|JAB1-containing signalosome subunit 3|signalosome subunit 3
Swissprots	O43191 B4DY81 Q7LDR6 Q9UNS2 B2R683
Accessions	EAW55711 EAW55712 EAW55713 Q9UNS2 AF031647 AAC14197 AF098109 AAD41247 AK297706 BAG60063 AK302304 BAG63643 AK312476 BAG35380 AK316400 BAH14771 BC001891 AAH01891 BP260214 BQ018146 BU952436 HQ447242 ADQ31729 XM_005256837 XP_005256894 XM_005256838 XP_005256895 XM_005256839 XP_005256896 XM_005256840 XP_005256897 XM_005256841 XP_005256898 XM_005256842 XP_005256899 NM_001199125 NP_001186054 NM_003653 NP_003644
Function	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
Tissue Specificity	Widely expressed. Expressed at high level in heart and skeletal muscle. {ECO:0000269|PubMed:10191102}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat COPS3 / CSN3 ELISA Kit (Cell-Based ELISA) - LS-F2093 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

COP9 signalosome complex subunit 3 (COPS3), Human, ELISA Kit - E01C1938 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Kappa-casein (CSN3), Human, ELISA Kit - E01K0085 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

COP9 signalosome complex subunit 3 (COPS3), ELISA Kit - MBS7200256 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 3 (COPS3), ELISA Kit - MBS7251758 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 3 (COPS3), ELISA Kit - MBS7221321 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 3 (COPS3), ELISA Kit - MBS7203412 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 3 (COPS3), ELISA Kit - MBS7252902 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

JAB1 Colorimetric Cell-Based ELISA Kit - CB5384 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

COP9 signalosome complex subunit 3 (COPS3), ELISA Kit - MBS7236016 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 3 (COPS3), ELISA Kit - MBS7250609 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 3 (COPS3), ELISA Kit - MBS7216574 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 3 (COPS3), ELISA Kit - MBS7239375 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 3 (COPS3), ELISA Kit - MBS7219156 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 3 (COPS3), ELISA Kit - MBS7204075 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 3 (COPS3), ELISA Kit - MBS7245808 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human CSN3 ELISA Kit - abx575410 from Abbexa Category ELISA Kit Sensitivity 11.8 ng/ml Range 31.25 ng/ml - 2000 ng/ml

Human CSN3 ELISA Kit - E006801 from Biobool Category ELISA Kit Sensitivity 1.56ug/ml

Human COPS3 ELISA Kit - E080289 from Biobool Category ELISA Kit

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