| Gene Symbol |
COPS3
|
| Entrez Gene |
8533
|
| Alt Symbol |
CSN3, SGN3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
COP9 signalosome subunit 3
|
| Other Description |
COP9 complex subunit 3|COP9 constitutive photomorphogenic homolog subunit 3|COP9 signalosome complex subunit 3|JAB1-containing signalosome subunit 3|signalosome subunit 3
|
| Swissprots |
O43191 B4DY81 Q7LDR6 Q9UNS2 B2R683
|
| Accessions |
EAW55711 EAW55712 EAW55713 Q9UNS2 AF031647 AAC14197 AF098109 AAD41247 AK297706 BAG60063 AK302304 BAG63643 AK312476 BAG35380 AK316400 BAH14771 BC001891 AAH01891 BP260214 BQ018146 BU952436 HQ447242 ADQ31729 XM_005256837 XP_005256894 XM_005256838 XP_005256895 XM_005256839 XP_005256896 XM_005256840 XP_005256897 XM_005256841 XP_005256898 XM_005256842 XP_005256899 NM_001199125 NP_001186054 NM_003653 NP_003644
|
| Function |
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
|
| Tissue Specificity |
Widely expressed. Expressed at high level in heart and skeletal muscle. {ECO:0000269|PubMed:10191102}.
|