COPS3

Gene Symbol COPS3
Entrez Gene 8533
Alt Symbol CSN3, SGN3
Species Human
Gene Type protein-coding
Description COP9 signalosome subunit 3
Other Description COP9 complex subunit 3|COP9 constitutive photomorphogenic homolog subunit 3|COP9 signalosome complex subunit 3|JAB1-containing signalosome subunit 3|signalosome subunit 3
Swissprots O43191 B4DY81 Q7LDR6 Q9UNS2 B2R683
Accessions EAW55711 EAW55712 EAW55713 Q9UNS2 AF031647 AAC14197 AF098109 AAD41247 AK297706 BAG60063 AK302304 BAG63643 AK312476 BAG35380 AK316400 BAH14771 BC001891 AAH01891 BP260214 BQ018146 BU952436 HQ447242 ADQ31729 XM_005256837 XP_005256894 XM_005256838 XP_005256895 XM_005256839 XP_005256896 XM_005256840 XP_005256897 XM_005256841 XP_005256898 XM_005256842 XP_005256899 NM_001199125 NP_001186054 NM_003653 NP_003644
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
Tissue Specificity Widely expressed. Expressed at high level in heart and skeletal muscle. {ECO:0000269|PubMed:10191102}.

CSN3 (H-300) - sc-367529 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CSN3 (H-300): sc-367529. Western blot analysis of CSN3 expression in Jurkat whole cell lysate.

CSN3 (C-17) - sc-47961 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CSN3 (C-17): sc-47961. Western blot analysis of CSN3 expression in U-251-MG (A), HEK293 (B) and PC-12 (C) whole cell lysates, HeLa nuclear extract (D) and mouse brain (E) and mouse uterus (F) tissue extracts.

CSN3 (K-18) - sc-47962 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CSN3 (RR12) - sc-100693 from Santa Cruz Biotechnology

Prices $295.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
CSN3 (RR12): sc-100693. Western blot analysis of CSN3 expression in HeLa whole cell lysate.

Anti-COPS3 antibody - ab113365 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Lane 1 : Anti-COPS3 antibody (ab113365) at 1 µg/mlLane 2 : Anti-COPS3 antibody (ab113365) at 1 mg/mlLane 3 : anti-DYKDDDDK tag at 1/5000 dilutionLane 1 : HEK293 lysate (in RIPA buffer) overexpressing Human COPS3 with DYKDDDDK tag Lane 2 : Mock transfected HEK293 lysate Lane 3 : HEK293 lysate (in RIPA buffer) overexpressing Human COPS3 with DYKDDDDK tag Lysates/proteins at 10 µg per lane.developed using the ECL technique

Anti-COPS3 antibody - ab196837 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of HeLa cells, treated with Forskolin (40nM, 30mins) labeling COPS3 with ab196837 at 1/100 dilution (left) and synthesized peptide (right ).

Anti-COPS3 antibody - ab12321 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohisotchemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate carcinoma tissue labelling COPS3 with ab12321 at 1/1000 (1µg/ml). Detection: DAB.

Anti-COPS3 antibody - ab82232 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-COPS3 antibody (ab82232) at 1/50 dilution + Ramos cell line lysates at 35 µg

Anti-COPS3 antibody - ab84432 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
etection of Human COPS3 by Immunohistochemistry.Sample: FFPE section of Human prostate adenocarcinoma.Antibody: ab84432 used at a dilution of 1/250.Detection: DAB staining.

Anti-COPS3 antibody - ab10463 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-COPS3 antibody - ab56377 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-COPS3 antibody [EPR3127] - ab79698 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3127
All lanes : Anti-COPS3 antibody [EPR3127] (ab79698) at 1/20000 dilutionLane 1 : HT-29 cell lysateLane 2 : HeLa cell lysateLane 3 : SKBR-3 cell lysateLane 4 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-COPS3 antibody - C-terminal - ab199637 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of HeLa cells, treated with Forskolin (40 nM, 30 minutes), labeling COPS3 with ab199637 at 1/100 dilution.

Anti-COPS3 Antibody - LS-C63936 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPS3 Antibody (Internal) - LS-C139705 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal

Anti-COPS3 Antibody (aa324-423, clone 10B2309, Azide-free) - LS-C183540 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10B2309

Anti-COPS3 Antibody (C-Terminus) - LS-C201735 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of Human Fetal Brain. COPS3 antibody dilution 1.0 ug/ml.

Anti-COPS3 Antibody (Met408) - LS-C176085 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of COPS3 (M408) pAb in extracts from LOVO cells.

Anti-COPS3 Antibody (aa306-355) - LS-C201736 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of Human Rat Testis . Cops3 antibody dilution 1.0 ug/ml.

Anti-COPS3 Antibody - LS-C307812 from LifeSpan Bioscience

Host Mouse
Clonality Polyclonal

Anti-COPS3 Antibody (aa324-423) - LS-C307813 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-COPS3 Antibody - LS-C309967 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPS3 Antibody (Internal) - LS-C97472 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of COPS3 (arrow) using rabbit polyclonal COPS3 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the COPS3 gene.

Anti-COPS3 Antibody (aa325-375) - LS-C286970 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Detection of Human CSN3 by Western Blot. Samples: Whole cell lysate (50 ug - E; 10 ug - T) from mock transfected (E) or CSN3 transfected (T) HEK293T cells. Antibody: Affinity purified rabbit anti-CSN3 used at the indicated concentration. Detection: Chemiluminescence with a 10 second exposure.

Anti-COPS3 Antibody (C-Terminus, clone EPR3127) - LS-C105553 from LifeSpan Bioscience

Host Rabbit
Clonality Monoclonal
Clone EPR3127
Immunofluorescent staining of HeLa cells using anti-COPS3 antibody (LS-C105553).
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