COPS3

Gene Symbol COPS3
Entrez Gene 8533
Alt Symbol CSN3, SGN3
Species Human
Gene Type protein-coding
Description COP9 signalosome subunit 3
Other Description COP9 complex subunit 3|COP9 constitutive photomorphogenic homolog subunit 3|COP9 signalosome complex subunit 3|JAB1-containing signalosome subunit 3|signalosome subunit 3
Swissprots O43191 B4DY81 Q7LDR6 Q9UNS2 B2R683
Accessions EAW55711 EAW55712 EAW55713 Q9UNS2 AF031647 AAC14197 AF098109 AAD41247 AK297706 BAG60063 AK302304 BAG63643 AK312476 BAG35380 AK316400 BAH14771 BC001891 AAH01891 BP260214 BQ018146 BU952436 HQ447242 ADQ31729 XM_005256837 XP_005256894 XM_005256838 XP_005256895 XM_005256839 XP_005256896 XM_005256840 XP_005256897 XM_005256841 XP_005256898 XM_005256842 XP_005256899 NM_001199125 NP_001186054 NM_003653 NP_003644
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
Tissue Specificity Widely expressed. Expressed at high level in heart and skeletal muscle. {ECO:0000269|PubMed:10191102}.

CSN3 CRISPR/Cas9 KO Plasmid (h) - sc-404478 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN3 HDR Plasmid (h) - sc-404478-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN3 Double Nickase Plasmid (h) - sc-404478-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN3 Double Nickase Plasmid (h2) - sc-404478-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN3 CRISPR Activation Plasmid (h) - sc-404478-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN3 CRISPR Activation Plasmid (h2) - sc-404478-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN3 Lentiviral Activation Particles (h) - sc-404478-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN3 Lentiviral Activation Particles (h2) - sc-404478-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN3 siRNA (h) - sc-60457 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CSN3 shRNA Plasmid (h) - sc-60457-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CSN3 shRNA (h) Lentiviral Particles - sc-60457-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

COP9 RNAi - H00008533-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU016431 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6433 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6433 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02118 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02118

COPS3 siRNA (Human) - CRH5604 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COPS3 - MBS8223862 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human COPS3 (NM_003653.3) - SHH267805 from Creative biogene

Category siRNA
Species Reactivities Human

COPS3 shRNA Plasmid (Human) - CHH5604 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

COPS3 miRNA 3'UTR clone - MiUTR3H-07000 from Creative biogene

Species Reactivities Human
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