COPS3

Gene Symbol	COPS3
Entrez Gene	8533
Alt Symbol	CSN3, SGN3
Species	Human
Gene Type	protein-coding
Description	COP9 signalosome subunit 3
Other Description	COP9 complex subunit 3|COP9 constitutive photomorphogenic homolog subunit 3|COP9 signalosome complex subunit 3|JAB1-containing signalosome subunit 3|signalosome subunit 3
Swissprots	O43191 B4DY81 Q7LDR6 Q9UNS2 B2R683
Accessions	EAW55711 EAW55712 EAW55713 Q9UNS2 AF031647 AAC14197 AF098109 AAD41247 AK297706 BAG60063 AK302304 BAG63643 AK312476 BAG35380 AK316400 BAH14771 BC001891 AAH01891 BP260214 BQ018146 BU952436 HQ447242 ADQ31729 XM_005256837 XP_005256894 XM_005256838 XP_005256895 XM_005256839 XP_005256896 XM_005256840 XP_005256897 XM_005256841 XP_005256898 XM_005256842 XP_005256899 NM_001199125 NP_001186054 NM_003653 NP_003644
Function	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
Tissue Specificity	Widely expressed. Expressed at high level in heart and skeletal muscle. {ECO:0000269|PubMed:10191102}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human COPS3 full length protein - ab132040 from Abcam Category Protein Source Wheat germ Species Human

Human CSN3 full length protein - ab158216 from Abcam Category Protein Source Wheat germ Species Human

Human CSN3 protein fragment - ab160079 from Abcam Category Protein Source Wheat germ Species Human

COPS3 Antibody Blocking Peptide - LS-E27492 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COPS3 Antibody Blocking Peptide - LS-E9325 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CSN3 / Kappa Casein Antibody Blocking Peptide - LS-E18686 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human COP9 Protein - H00008533-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CSN3 Protein - H00001448-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human COP9 Protein - H00008533-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

COPS3-Antibody-Center-Blocking-Peptide - BP7863c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CSN3 Blocking Peptide - 33R-6168 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

COPS3 Blocking Peptide - abx063488 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Dog, Monkey, Pig

COPS3 Peptide - AC21-2315-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

COPS3 - H00008533-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

COPS3 - H00008533-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

COPS3 - H00008533-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

COPS3 - H00008533-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

COPS3 Peptide - 42-405P from ProSci Category Peptide Species Human

COPS3 fusion protein - ag7968 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

COPS3 Blocking Peptide - CBP2294 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Dog, Monkey, Pig

COPS3 (M408) Peptide - BS1192P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human COP9 signalosome complex subunit 3(COPS3) - CSB-YP892483HU CSB-EP892483HU CSB-BP892483HU CSB-MP892483HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

COPS3, Peptide - MBS427683 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

CSN3 Recombinant Protein Antigen - NBP1-85436PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

COP9 Recombinant Protein Antigen - NBP1-85435PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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