CASP2

Gene Symbol CASP2
Entrez Gene 835
Alt Symbol CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57
Species Human
Gene Type protein-coding
Description caspase 2, apoptosis-related cysteine peptidase
Other Description caspase-2|neural precursor cell expressed developmentally down-regulated protein 2|protease ICH-1|protein phosphatase 1, regulatory subunit 57
Swissprots Q59F21 Q9BZL0 D3DXD6 Q9BZK9 E9PDN0 A8K5F9 Q9BUP7 P42575 Q7KZL6 P42576 Q86UJ3
Accessions AAO25653 AAP22346 AAP22347 AAP22348 AAP22349 EAW51860 EAW51862 EAW51863 EAW51864 EAW51867 EAW51869 EAW51870 P42575 AB209640 BAD92877 AF314174 AAK00299 AF314175 AAK00300 AK096245 AK291274 BAF83963 AK303265 BAG64347 AK303391 BAG64447 BC002427 AAH02427 BG397039 BM998653 BQ447606 BT007240 AAP35904 BX537669 CB988674 CR541748 CAG46548 DA505883 DB455837 DB455840 DQ893820 ABM84746 U13021 AAA58959 U13022 AAA58960 NM_001224 NP_001215 NM_032982 NP_116764 NM_032983 NP_116765
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.
Tissue Specificity Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.

Caspase-2 (C2) Mouse mAb - 2224 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone C2
Western blot analysis of extracts from Jurkat cells, untreated or etoposide-treated (5 hr, 25μM), using Caspase-2 (C2) Mouse mAb.

caspase-2 (H-145) - sc-15379 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
caspase-2 (H-145): sc-15379. Western blot analysis of human recombinant caspase-2.

caspase-2 (H-19) - sc-623 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
caspase-2 (H-19): sc-623. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse testis showing cytoplasmic localization.

caspase-2 (1C10) - sc-53928 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
caspase-2 (1C10): sc-53928. Western blot analysis of caspase-2 expression in Ramos (A) and Jurkat (B) whole cell lysates.

caspase-2 L (C-19) - sc-626 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
caspase-2<sub>L</sub> (C-19): sc-626. Western blot analysis of caspase-2<sub>L</sub> (Nedd-2) precursor expression in WEHI-3 whole cell lysate.

caspase-2 L (C-20) - sc-625 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of caspase-2<sub>L</sub> (ICH-1L) precursor expression in Jurkat (A,D), MOLT-4 (B,C) and HeLa (E) whole cell lysates. Antibodies tested include caspase-2<sub>L</sub> (C-20)-G: sc-625-G (A,B) and caspase-2<sub>L</sub> (C-20): sc-625 (C-E).

caspase-2 L (F-7) - sc-5292 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
caspase 2<sub>L</sub> (F-7): sc-5292. Western blot analysis of caspase 2<sub>L</sub> precursor expression in HeLa (A), MOLT-4 (B) and Jurkat (C) whole cell lysates.

caspase-2 L (H-119) - sc-8985 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
caspase-2<sub>L</sub> (H-119): sc-8985. Western blot analysis of caspase-2<sub>L</sub> expression in MOLT-4 whole cell lysate.

caspase-2 L (35) - sc-136218 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
caspase-2L (35): sc-136218. Western blot analysis of caspase-2L expression in Jurkat whole cell lysate.

cleaved caspase-2 p12 (h331) - sc-22169 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
cleaved caspase-2 p12 (h331): sc-22169. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing nuclear staining of cells in glomeruli and cytoplasmic and nuclear staining of cells in tubules.

caspase-2 (F-2) - sc-514472 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
caspase-2 (F-2): sc-514472. Western blot analysis of caspase-2 expression in MOLT-4 (A), Jurkat (B) and HuT 78 (C) whole cell lysates.

Anti-Caspase 2 antibody - ab182657 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human urinary bladder tissue labeling active Caspase  2 using ab182657 at 1/100 dilution. The right panel is treated with the fusion protein.

Anti-Caspase-2 (phospho S157) antibody - ab62441 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of Caspase-2 in human lung carcinoma tissue (paraffin section), using ab62441 (1:50); in the presence or absence of phosphopeptide.

Anti-Caspase-2 antibody - ab74127 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of Caspase-2 in paraffin embedded human lung carcinoma tissue using ab74127 at a 1:50 dilution. Left hand panel: no peptide. Right hand panel: peptide present.

Anti-Caspase-2 antibody - ab22686 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Caspase-2 antibody (ab22686) at 1/20000 dilutionLane 1 : human recombinant caspase 1Lane 2 : human recombinant caspsase 2Lysates/proteins at 0.05 µg per lane.Secondarygoat anti rabbit AP at 1/2000 dilutionPerformed under reducing conditions.

Anti-Caspase-2 antibody - ab407 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Caspase-2 antibody [EPR16796] - ab179520 from Abcam

Prices $347.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR16796
All lanes : Anti-Caspase-2 antibody [EPR16796] (ab179520) at 1/2000 dilutionLane 1 : HeLa (Human epithelial cells from cervix adenocarcinoma) whole cell lysate treated with 4uM camptothecin for 4 hoursLane 2 : Untreated HeLa whole cell lysateLane 3 : C6 (Rat glial tumor cells) whole cell lysate treated with 1uM staurosporine for 4 hoursLane 4 : Untreated C6 whole cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/1000 dilution

Anti-Caspase-2 antibody [EPR17880] - ab202420 from Abcam

Prices $347.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR17880
All lanes : Anti-Caspase-2 antibody [EPR17880] (ab202420) at 1/10000 dilutionLane 1 : Jurkat (Human T cell leukemia cells from peripheral blood) treated with 25uM etoposide for 5 hours whole cell lysatesLane 2 : Untreated Jurkat (Human T cell leukemia cells from peripheral blood) whole cell lysatesLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-Caspase-2 antibody [EPR17881] - ab182738 from Abcam

Prices $382.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR17881
All lanes : Anti-Caspase-2 antibody [EPR17881] (ab182738) at 1/2000 dilutionLane 1 : Jurkat whole cell lysates(Human T cell leukemia cells from peripheral blood) treated with 25uM etoposide for 5 hoursLane 2 : Untreated Jurkat whole cell lysatesLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/1000 dilution

Anti-Caspase-2 antibody [SB123a] - ab87019 from Abcam

Prices $376.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone SB123a
Anti-Caspase-2 antibody [SB123a] (ab87019) at 4 µg/ml + Jurkat cells stimulated with anti-DR5SecondaryHRP-conjugated Goat anti-Rat IgMObserved band size : 40 + 48 kDa (why is the actual band size different from the predicted?)

Anti-Caspase-2 antibody [Y154] - ab32021 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y154
Anti-Caspase-2 antibody [Y154] (ab32021) at 1/500 dilution + Jurkat cell lysate.

Anti-CASP2 / Caspase 2 Antibody (aa32-169) - LS-C127261 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-CASP2 / Caspase 2 Antibody (N-Terminus) - LS-C121480 from LifeSpan Bioscience

Prices $695.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-CASP2 / Caspase 2 Antibody (aa32-169, clone 1C10) - LS-C93694 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C10
Cell lysates of Ramos and Jurkat (each 40 ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human Caspase-2(1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and a ECL detection system. Lane 1: Ramos; Lane 2: Jurkat.

Anti-CASP2 / Caspase 2 Antibody (C-Terminus, clone Y154) - LS-C49531 from LifeSpan Bioscience

Prices $480.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y154
Western blot analysis on Jurkat cell lysate using anti-Caspase-2 antibody, dilution 1:500.
Search more