ITGB3BP

Gene Symbol ITGB3BP
Entrez Gene 23421
Alt Symbol CENP-R, CENPR, HSU37139, NRIF3, TAP20
Species Human
Gene Type protein-coding
Description integrin beta 3 binding protein (beta3-endonexin)
Other Description beta 3 endonexin|beta-3-endonexin|centromere protein R|integrin beta-3-binding protein|nuclear receptor-interacting factor 3
Swissprots Q5RJ45 Q13353 Q9UKB6 Q96CD5 Q5RJ42 Q7KYX2 B2R7D8 Q5RJ44 Q13352
Accessions EAX06561 EAX06562 EAX06563 EAX06564 EAX06565 EAX06566 EAX06567 Q13352 AA873717 AF175306 AAF00239 AK309622 AK312944 BAG35785 BC009929 AAH09929 BC014385 AAH14385 BU853146 U37139 AAC50294 XM_006710514 XP_006710577 XM_006710515 XP_006710578 XM_011541130 XP_011539432 XM_011541131 XP_011539433 NM_001206739 NP_001193668 NM_014288 NP_055103 NR_045147
Function Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF- kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A- associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore prote
Subcellular Location Isoform 3: Nucleus. Cytoplasm. Note=Isoform 3 is predominantly nuclear and weakly cytoplasmic.
Tissue Specificity Widely expressed. Expressed in spleen, thymus, prostate, ovary, small intestine and white blood cells. Highly expressed in testis and colon. Isoform 4 is expressed in platelets, lymphocytes and granulocytes. {ECO:0000269|PubMed:11864709, ECO:0000269|PubMed:7593198}.

Centromere protein R (ITGB3BP), Human, ELISA Kit - E01C0939 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t
Sensitivity 0.1ng/ml
Range 1.0-25ng/ml

Centromere protein R (ITGB3BP), Human, ELISA Kit - E01C2312 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Centromere protein R (ITGB3BP), ELISA Kit - MBS7233540 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Centromere protein R (ITGB3BP), ELISA Kit - MBS7215881 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Centromere protein R (ITGB3BP), ELISA Kit - MBS7251228 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Centromere protein R (ITGB3BP), ELISA Kit - MBS7224349 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Centromere protein R (ITGB3BP), ELISA Kit - MBS7215925 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Centromere protein R (ITGB3BP), ELISA Kit - MBS7202363 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Centromere protein R (ITGB3BP), ELISA Kit - MBS7250493 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Centromere protein R (ITGB3BP), ELISA Kit - MBS7210310 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Centromere protein R (ITGB3BP), ELISA Kit - MBS7214448 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Centromere protein R (ITGB3BP), ELISA Kit - MBS7245444 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Centromere protein R (ITGB3BP), ELISA Kit - MBS7251108 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Centromere protein R (ITGB3BP), ELISA Kit - MBS7219661 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human ITGB3BP ELISA Kit - E078350 from Biobool

Category ELISA Kit
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