| Gene Symbol |
ITGB3BP
|
| Entrez Gene |
23421
|
| Alt Symbol |
CENP-R, CENPR, HSU37139, NRIF3, TAP20
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
integrin beta 3 binding protein (beta3-endonexin)
|
| Other Description |
beta 3 endonexin|beta-3-endonexin|centromere protein R|integrin beta-3-binding protein|nuclear receptor-interacting factor 3
|
| Swissprots |
Q5RJ45 Q13353 Q9UKB6 Q96CD5 Q5RJ42 Q7KYX2 B2R7D8 Q5RJ44 Q13352
|
| Accessions |
EAX06561 EAX06562 EAX06563 EAX06564 EAX06565 EAX06566 EAX06567 Q13352 AA873717 AF175306 AAF00239 AK309622 AK312944 BAG35785 BC009929 AAH09929 BC014385 AAH14385 BU853146 U37139 AAC50294 XM_006710514 XP_006710577 XM_006710515 XP_006710578 XM_011541130 XP_011539432 XM_011541131 XP_011539433 NM_001206739 NP_001193668 NM_014288 NP_055103 NR_045147
|
| Function |
Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF- kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A- associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore prote
|
| Subcellular Location |
Isoform 3: Nucleus. Cytoplasm. Note=Isoform 3 is predominantly nuclear and weakly cytoplasmic.
|
| Tissue Specificity |
Widely expressed. Expressed in spleen, thymus, prostate, ovary, small intestine and white blood cells. Highly expressed in testis and colon. Isoform 4 is expressed in platelets, lymphocytes and granulocytes. {ECO:0000269|PubMed:11864709, ECO:0000269|PubMed:7593198}.
|